Ethyl α-Fluoro Silyl Enol Ether:  Stereoselective Synthesis and Its
Aldol Reaction with Aldehydes and Ketones

Chen, Qing-Yun

Ethyl α-Fluoro Silyl Enol Ether: Stereoselective Synthesis and Its Aldol Reaction with Aldehydes and Ketones

Posted on 2002-04-18 - 00:00

Ethyl α-fluoro silyl enol ether is stereoselectively synthesized in high yield from inexpensive chlorofluoroacetate and Mg (or Zn) in DMF (or HMPA). Lewis acid promoted aldol reaction of this enol ether with aldehydes and ketones gives α-fluoro-β-hydroxy esters in good to excellent yields.

CITE THIS COLLECTION

Huang, Xiao-Ting; Chen, Qing-Yun (2016). Ethyl α-Fluoro Silyl Enol Ether: Stereoselective Synthesis and Its Aldol Reaction with Aldehydes and Ketones. ACS Publications. Collection. https://doi.org/10.1021/jo010820+

https://doi.org/10.1021/jo010820+

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