Enantioselective Copper-Catalyzed Methylboration of
Alkenes

Liao, Jian

Enantioselective Copper-Catalyzed Methylboration of Alkenes

Posted on 2018-02-20 - 20:16

An enantioselective Cu-catalyzed borylative cross-coupling reaction of alkenes, bis(pinacolato)diboron (B₂(pin)₂), and methyl iodide is reported. Alkenes including styrenes, β-substituted styrenes, and challenging aliphatic olefins were smoothly transferred to the desired methylboration products with excellent diastereoselectivities (dr up to >99:1) and enantioselectivities (er up to 99:1). The utility of this process was demonstrated by the synthesis of naproxen and formal synthesis of two natural products.

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Chen, Bin; Cao, Peng; Liao, Yang; Wang, Min; Liao, Jian (2018). Enantioselective Copper-Catalyzed Methylboration of Alkenes. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b03860

https://doi.org/10.1021/acs.orglett.7b03860

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