Enantioselective 1,4-Addition of
Unmodified Ketone Catalyzed by a
Bimetallic Zn−Zn-Linked−BINOL
Complex

Shibasaki, Masakatsu

Enantioselective 1,4-Addition of Unmodified Ketone Catalyzed by a Bimetallic Zn−Zn-Linked−BINOL Complex

Posted on 2001-12-05 - 00:00

1,4-Addition (Michael addition) of 2-hydroxy-2‘-methoxyacetophenone (2) to various α,β-unsaturated ketones was efficiently promoted by a bimetallic Zn−Zn-linked−BINOL complex 3 with good yield (up to 90%) and excellent enantiomeric excess (up to 99% ee). The resulting 2-hydroxy-1,5-diketones were successfully converted to synthetically more versatile esters and amides.

CITE THIS COLLECTION

Kumagai, Naoya; Matsunaga, Shigeki; Shibasaki, Masakatsu (2016). Enantioselective 1,4-Addition of Unmodified Ketone Catalyzed by a Bimetallic Zn−Zn-Linked−BINOL Complex. ACS Publications. Collection. https://doi.org/10.1021/ol016981h

https://doi.org/10.1021/ol016981h

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