Emeriones A–C: Three Highly Methylated Polyketides
with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities
from Emericella nidulans
Posted on 2019-06-19 - 19:18
Emeriones A–C (1–3), three
highly methylated polyketides with bicyclo[4.2.0]octene and 3,6-dioxabicyclo[3.1.0]hexane
functionalities, were isolated from Emericella nidulans. An additional peroxide bridge in compound 3 led to
the construction of an unexpected 7,8-dioxatricyclo[4.2.2.02,5]decene scaffold. The structures of 1–3 were elucidated by comprehensive spectroscopic techniques, and their
absolute configurations were confirmed by single-crystal X-ray crystallographic
analyses and ECD calculations. Compound 1 shows weak
inhibitory effects on NO production in LPS-induced RAW264.7 cells.
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Li, Qin; Chen, Chunmei; He, Yan; Guan, Danyingzi; Cheng, Li; Hao, Xincai; et al. (2019). Emeriones A–C: Three Highly Methylated Polyketides
with Bicyclo[4.2.0]octene and 3,6-Dioxabicyclo[3.1.0]hexane Functionalities
from Emericella nidulans. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.9b01680
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AUTHORS (13)
QL
Qin Li
CC
Chunmei Chen
YH
Yan He
DG
Danyingzi Guan
LC
Li Cheng
XH
Xincai Hao
MW
Mengsha Wei
YZ
Yinyu Zheng
CL
Chang Liu
XL
Xiao-Nian Li
QZ
Qun Zhou
HZ
Hucheng Zhu
YZ
Yonghui Zhang
KEYWORDS
dioxatricycloCompound 1Emericella nidulans EmerionesDioxabicycloFunctionalitiecompound 3bicycloperoxide bridgeEmericella nidulansspectroscopic techniquesMethylated Polyketidesdioxabicyclofunctionalitiesingle-crystal X-rayconstructionmethylated polyketidesanalysesconfigurationECD calculationsBicycloLPS-induced RAW 264.7 cellsscaffolddecene