Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
Posted on 2019-06-12 - 08:30
This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.
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Yoshida, Keimei; Saku, Keita; Kamada, Kazuhiro; Abe, Kohtaro; Tanaka-Ishikawa, Mariko; Tohyama, Takeshi; et al. (2019). Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. JACC: Basic to Translational Science. Collection. https://doi.org/10.25407/JACBTS.c.4538342.v1
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AUTHORS (10)
KY
Keimei Yoshida
KS
Keita Saku
KK
Kazuhiro Kamada
KA
Kohtaro Abe
MT
Mariko Tanaka-Ishikawa
TT
Takeshi Tohyama
TN
Takuya Nishikawa
TK
Takuya Kishi
KS
Kenji Sunagawa
HT
Hiroyuki Tsutsui