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Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Posted on 2019-06-12 - 08:30
This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.

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Journal of the American College of Cardiology

AUTHORS (10)

Keimei Yoshida
Keita Saku
Kazuhiro Kamada
Kohtaro Abe
Mariko Tanaka-Ishikawa
Takeshi Tohyama
Takuya Nishikawa
Takuya Kishi
Kenji Sunagawa
Hiroyuki Tsutsui
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