Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Published on 2017-08-12T13:13:39Z (GMT) by
Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).

Cite this collection

Haftchenary, Sina; Nelson, Shawn D.; Furst, Laura; Dandapani, Sivaraman; Ferrara, Steven J.; Bošković, Žarko V.; Figueroa Lazú, Samuel; Guerrero, Adrian M.; Serrano, Juan C.; Crews, DeMarcus K.; Brackeen, Cristina; Mowat, Jeffrey; Brumby, Thomas; Bauser, Marcus; Schreiber, Stuart L.; Phillips, Andrew J. (2017): Efficient Routes to a Diverse Array of Amino Alcohol-Derived

Chiral Fragments. ACS Publications.

https://doi.org/10.1021/acscombsci.6b00050

Retrieved: 08:50, Aug 24, 2017 (GMT)