Efficient Routes to a Diverse Array of Amino Alcohol-Derived
Chiral Fragments
Version 3 2017-08-12, 13:13
Version 2 2016-09-06, 14:49
Version 1 2016-08-12, 17:19
Posted on 2017-08-12 - 13:13
Efficient
syntheses of chiral fragments derived from chiral amino
alcohols are described. Several unique scaffolds were readily accessed
in 1–5 synthetic steps leading to 45 chiral fragments, including
oxazolidinones, morpholinones, lactams, and sultams. These fragments
have molecular weights ranging from 100 to 255 Da and are soluble
in water (0.085 to >15 mM).
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Haftchenary, Sina; Nelson, Shawn D.; Furst, Laura; Dandapani, Sivaraman; Ferrara, Steven J.; Bošković, Žarko V.; et al. (2016). Efficient Routes to a Diverse Array of Amino Alcohol-Derived
Chiral Fragments. ACS Publications. Collection. https://doi.org/10.1021/acscombsci.6b00050
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AUTHORS (16)
SH
Sina Haftchenary
SN
Shawn D. Nelson
LF
Laura Furst
SD
Sivaraman Dandapani
SF
Steven J. Ferrara
ZB
Žarko V. Bošković
SF
Samuel Figueroa Lazú
AG
Adrian M. Guerrero
JS
Juan C. Serrano
DC
DeMarcus K. Crews
CB
Cristina Brackeen
JM
Jeffrey Mowat
TB
Thomas Brumby
MB
Marcus Bauser
SS
Stuart L. Schreiber
AP
Andrew J. Phillips