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Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

Version 3 2017-08-12, 13:13
Version 2 2016-09-06, 14:49
Version 1 2016-08-12, 17:19
Posted on 2017-08-12 - 13:13
Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).

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ACS Combinatorial Science

AUTHORS (16)

Sina Haftchenary
Shawn D. Nelson
Laura Furst
Sivaraman Dandapani
Steven J. Ferrara
Žarko V. Bošković
Samuel Figueroa Lazú
Adrian M. Guerrero
Juan C. Serrano
DeMarcus K. Crews
Cristina Brackeen
Jeffrey Mowat
Thomas Brumby
Marcus Bauser
Stuart L. Schreiber
Andrew J. Phillips
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