Efficient Construction of Stereodefined α-Alkylidene Aza-cycloketones via β-Amino-alkenyllithium: Straightforward and Protection-Free Synthesis of Allopumiliotoxin 267A
Posted on 2009-05-07 - 00:00
Intramolecular nucleophilic acyl substitution of highly functionalized β-amino-alkenyllithium species provided facile access to α-alkylidene aza-cycloketones with defined olefin geometry and rich structural diversity. A concise total synthesis of allopumiliotoxin 267A has been accomplished in 5 steps from 4 featuring this key transformation.
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Wang, Bing; Zhong, Zheng; Lin, Guo-Qiang (2016). Efficient Construction of Stereodefined α-Alkylidene Aza-cycloketones via β-Amino-alkenyllithium: Straightforward and Protection-Free Synthesis of Allopumiliotoxin 267A. ACS Publications. Collection. https://doi.org/10.1021/ol900452n
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