Donor–Acceptor-Type Supramolecular Polymers
Derived from Robust yet Responsive Heterodimeric Tweezers
Version 2 2016-09-07, 13:13
Version 1 2016-08-26, 18:33
Posted on 2016-08-26 - 00:00
Molecular
tweezer/guest recognition has emerged as a novel motif
for the construction of supramolecular polymers. However, the overwhelming
majority of ADA- or DAD-type (D = donor, A = acceptor) molecular tweezer/guest
recognition systems suffer from relatively low binding affinities
and inconspicuous variations toward external stimuli. To address this
issue, herein a novel heterodimeric DADA-type complex has been designed
and constructed. By engineering of donor–acceptor and hydrogen-bonding
interactions, it demonstrates 1000 times enhancement for the complexation
strength (Ka = 2.23 × 106 M–1) than the ADA-type counterpart. Moreover,
by modulating the intermolecular hydrogen bonds involved in the system,
its binding affinity exhibits significantly large variations toward
external stimuli (∼102–103-fold
change for Ka). The robust yet adaptive
heterodimeric complex is employed as a tecton for the fabrication
of high-molecular-weight donor–acceptor-type supramolecular
polymers, demonstrating the efficiency and versatility to develop
self-assembled materials via rational engineering of fundamental noncovalent
recognition motifs.
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Tian, Yu-Kui; Han, Yi-Fei; Yang, Zhi-Shuai; Wang, Feng (2016). Donor–Acceptor-Type Supramolecular Polymers
Derived from Robust yet Responsive Heterodimeric Tweezers. ACS Publications. Collection. https://doi.org/10.1021/acs.macromol.6b01032
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AUTHORS (4)
YT
Yu-Kui Tian
YH
Yi-Fei Han
ZY
Zhi-Shuai Yang
FW
Feng Wang
KEYWORDS
binding affinitiesnovel motif1000 times enhancementcomplexation strengthsupramolecular polymersbinding affinity exhibitsself-assembled materialsadaptive heterodimericADA-type counterpartnoncovalent recognition motifsnovel heterodimeric DADA-typehydrogen-bonding interactionstweezerdonorhydrogen bondsvariationstimuli