Domino Reaction of Pyrrolidinium Ylides: Michael Addition/[1,2]-Stevens Rearrangement

Published on 2018-03-13T14:23:11Z (GMT) by
A novel domino reaction featuring a Michael addition/[1,2]-Stevens rearrangement reaction of pyrrolidinium ylides with electrophilic alkenes is described. Ylides generated under mild conditions from 2-aryl-<i>N</i>-cyanomethyl-<i>N</i>-methylpyrrolidinium salts entered the Michael addition, followed by a [1,3]-hydrogen shift and finally the [1,2]-Stevens rearrangement to give 3-aryl-2-cyano-2-(2-EWG-ethyl)-1-methylpiperidines.

Cite this collection

Kowalkowska, Anna; Jończyk, Andrzej; Maurin, Jan K. (2018): Domino Reaction of Pyrrolidinium

Ylides: Michael Addition/[1,2]-Stevens

Rearrangement. ACS Publications. Collection.