Directed γ‑C(sp<sup>3</sup>)–H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis

Published on 2017-10-12T13:56:10Z (GMT) by
Visible light photoredox catalysis enables direct γ- C­(sp<sup>3</sup>)–H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated <i>in situ</i>.

Cite this collection

Chen, Dian-Feng; C. K. Chu, John; Rovis, Tomislav (2017): Directed

γ‑C(sp3)–H

Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox

Catalysis. ACS Publications.