Direct Synthesis of Acyl Fluorides from Carboxylic
Acids with the Bench-Stable Solid Reagent (Me4N)SCF3
Posted on 2017-10-12 - 19:48
A convenient, highly
efficient, and selective transformation of
aliphatic and aromatic carboxylic acids to acyl fluorides is reported.
In contrast to established approaches that require toxic or volatile
additives and base and reaction control (i.e., cooling, slow addition),
this protocol allows for a straightforward access to various R-COF
entities upon direct reaction with the bench-stable, solid reagent
(Me4N)SCF3 at room temperature. The method is
base- and additive-free, compatible with late-stage synthetic applications,
high functional group tolerance, and facile target compound purification
via filtration.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Scattolin, Thomas; Deckers, Kristina; Schoenebeck, Franziska (2017). Direct Synthesis of Acyl Fluorides from Carboxylic
Acids with the Bench-Stable Solid Reagent (Me4N)SCF3. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b02516
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (3)
TS
Thomas Scattolin
KD
Kristina Deckers
FS
Franziska Schoenebeck
KEYWORDS
entityaliphaticBench-Stablecarboxylic acidsacyl fluoridesaccessadditiveapplicationCarboxylic Acidscoolingtarget compound purificationReagentroom temperatureadditive-freeapproachtransformationcontrastreaction controlbench-stablereagentfiltrationi.eAcyl FluoridesR-COF entitiesgroup tolerancemethodDirect Synthesislate-stage