Diastereoselective Synthesis of Diquinanes and Triquinanes Bearing Vicinal Quaternary Carbon Stereocenters from Acyclic Allene-based Precursors via a Cascade Reaction

Published on 2017-08-11T18:33:53Z (GMT) by
A cascade benzenethiol-mediated intramolecular [3 + 2] cycloaddition reaction between an allene and an α,β-unsaturated aldehyde or ester is developed for the diastereoselective synthesis of [3.3.0] bicyclic system bearing two quaternary atoms at their bridgehead positions. Notably, these structurally complex systems can be found in a wide range of natural products.

Cite this collection

Li, Shuang; Zhang, Pengpeng; Li, Yuanhe; Lu, Shumin; Gong, Jianxian; Yang, Zhen (2017): Diastereoselective Synthesis of Diquinanes and Triquinanes

Bearing Vicinal Quaternary Carbon Stereocenters from Acyclic Allene-based

Precursors via a Cascade Reaction. ACS Publications.

https://doi.org/10.1021/acs.orglett.7b01733

Retrieved: 11:51, Oct 23, 2017 (GMT)