Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Green, Alanna C.

Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Posted on 2024-01-02 - 08:20

Abstract

The one-carbon folate enzyme methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2) is a promising therapeutic target in cancer. MTHFD2 is upregulated across numerous cancer types, promotes growth and metastasis of cancer, and correlates with poorer survival. Recent studies have developed small-molecule inhibitors to the isozymes MTHFD2 and MTHFD1 that show promise as anticancer agents through different mechanisms. This review discusses the current understanding of the function of MTHFD2 in cancer and the status of inhibitors for treating MTHFD2-overexpressing cancers.

CITE THIS COLLECTION

Ramos, Louise; Henriksson, Martin; Helleday, Thomas; Green, Alanna C. (2024). Data from Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response. American Association for Cancer Research. Collection. https://doi.org/10.1158/0008-5472.c.7002653.v1

https://doi.org/10.1158/0008-5472.c.7002653.v1

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