Copper-Promoted Regioselective
Intermolecular Diamination of Ynamides:
Synthesis of Imidazo[1,2‑a]pyridines

Reddy, Maddi Sridhar

Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑a]pyridines

Posted on 2017-06-19 - 13:12

A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo[1,2-a]pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu(OTf)₂-mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3.

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Dwivedi, Vikas; Kumar, Ravi; Sharma, Kavita; Sridhar, Balasubramanian; Reddy, Maddi Sridhar (2017). Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑a]pyridines. ACS Publications. Collection. https://doi.org/10.1021/acsomega.7b00426

https://doi.org/10.1021/acsomega.7b00426

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