Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑<i>a</i>]pyridines
Published on 2017-06-19T13:12:52Z (GMT) by
A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo[1,2-<i>a</i>]pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu(OTf)<sub>2</sub>-mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3.
Cite this collection
Dwivedi, Vikas; Kumar, Ravi; Sharma, Kavita; Sridhar, Balasubramanian; Reddy, Maddi Sridhar (2017): Copper-Promoted Regioselective
Intermolecular Diamination of Ynamides:
Synthesis of Imidazo[1,2‑a]pyridines. ACS Publications.