Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2‑<i>a</i>]pyridines

Published on 2017-06-19T13:12:52Z (GMT) by
A facile access to 3-heterosubstituted (3-oxazolidinonyl/indolyl/phenoxy) imidazo­[1,2-<i>a</i>]­pyridines from readily available 2-aminopyridines and electron-rich (internally activated) alkynes like ynamides/ynamines/ynol ethers is achieved via Cu­(OTf)<sub>2</sub>-mediated intermolecular diamination under aerobic conditions. The reaction is highly regioselective, owing to internal electron bias, and thus led to a single regioisomer with heterosubstitution at C3.

Cite this collection

Dwivedi, Vikas; Kumar, Ravi; Sharma, Kavita; Sridhar, Balasubramanian; Reddy, Maddi Sridhar (2017): Copper-Promoted Regioselective

Intermolecular Diamination of Ynamides:

Synthesis of Imidazo[1,2‑a]pyridines. ACS Publications.

https://doi.org/10.1021/acsomega.7b00426

Retrieved: 00:08, Jun 26, 2017 (GMT)