Copper-Catalyzed <i>ipso</i>-Borylation of Fluoroarenes
Published on 2017-06-17T13:29:32Z (GMT) by
<i>ipso</i>-Borylation of fluoroarenes has been achieved using an air-stable copper complex as a catalyst. Mechanistic studies suggest that the reaction proceeds via an S<sub>RN</sub>1 mechanism involving a single-electron-transfer (SET) process and not via the typical S<sub>N</sub>Ar mechanism. This method differs from the previously reported nickel/copper-cocatalyzed system in terms of scope of the substrate and has exhibited good scalability. Double and triple <i>ipso</i>-borylations of several di- and trifluoroarenes have been also achieved efficiently, enhancing the synthetic utility of this method.