Cobalt-Catalyzed Hydroboration of Alkenes, Aldehydes,
and Ketones

Findlater, Michael

Cobalt-Catalyzed Hydroboration of Alkenes, Aldehydes, and Ketones

Posted on 2018-10-19 - 19:03

An operationally convenient and general method for hydroboration of alkenes, aldehydes, and ketones employing Co(acac)₃ as a precatalyst is reported. The hydroboration of alkenes in the presence of HBpin, PPh₃, and NaO^tBu affords good to excellent yields with high Markovnikov selectivity with up to 97:3 branched/linear selectivity. Moreover, Co(acac)₃ could be used effectively to hydroborate aldehydes and ketones in the absence of additives under mild reaction conditions. Inter- and intramolecular chemoselective reduction of the aldehyde group took place over the ketone functional group.

CITE THIS COLLECTION

DataCite

3 Biotech

3D Printing in Medicine

3D Research

3D-Printed Materials and Systems

4OR

AAPG Bulletin

AAPS Open

AAPS PharmSciTech

Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg

ABI Technik (German)

Academic Medicine

Academic Pediatrics

Academic Psychiatry

Academic Questions

Academy of Management Discoveries

Academy of Management Journal

Academy of Management Learning and Education

Academy of Management Perspectives

Academy of Management Proceedings

Academy of Management Review

Tamang, Sem Raj; Bedi, Deepika; Shafiei-Haghighi, Sara; Smith, Cecilia R.; Crawford, Christian; Findlater, Michael (2018). Cobalt-Catalyzed Hydroboration of Alkenes, Aldehydes, and Ketones. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b02775

https://doi.org/10.1021/acs.orglett.8b02775

or

Select your citation style and then place your mouse over the citation text to select it.