Chiral Resolution of RS-Oxiracetam
upon Cocrystallization with Pharmaceutically Acceptable Inorganic
Salts

Leyssens, Tom

Chiral Resolution of RS-Oxiracetam upon Cocrystallization with Pharmaceutically Acceptable Inorganic Salts

Posted on 2020-02-28 - 20:37

Ionic cocrystals (ICCs) of racemic RS-oxiracetam and of its active S-enantiomer of pharmaceutical interest with the pharmaceutically acceptable salts calcium and magnesium chloride were synthesized and structurally characterized. The cocrystallization of RS-oxiracetam with MgCl₂ resulted in chiral resolution with formation of an S-OXI·MgCl₂·5H₂O/R-OXI·MgCl₂·5H₂O conglomerate. Ternary phase diagrams of RS-oxiracetam/inorganic salt/solvent were constructed to determine the overall compositions for which the ICCs are the only stable phases in suspension. In addition, single crystals of S-oxiracetam were grown, and its structure was determined.

CITE THIS COLLECTION

Shemchuk, Oleksii; Song, Lixing; Tumanov, Nikolay; Wouters, Johan; Braga, Dario; Grepioni, Fabrizia; et al. (2020). Chiral Resolution of RS-Oxiracetam upon Cocrystallization with Pharmaceutically Acceptable Inorganic Salts. ACS Publications. Collection. https://doi.org/10.1021/acs.cgd.9b01725

https://doi.org/10.1021/acs.cgd.9b01725

or

Select your citation style and then place your mouse over the citation text to select it.