Chicory Roots for Prebiotics and Appetite Regulation:
A Pilot Study in Mice
Version 2 2018-06-13, 13:51
Version 1 2018-06-12, 17:53
Posted on 2018-06-13 - 13:51
The
objectives of this work are to address the prebiotic effects
of chicory (Cichorium intybus) together with its
possible role in appetite control. We compared nine chicory genotypes
in order to determine if variations in the content of metabolites
in the roasted roots would lead to modifications in release of satiety
hormones and in composition of gut microbiota. To this aim, a 5-week
dietary-intervention study was achieved using mice fed with distinct
chicory-based preparations. A 16S rRNA gene-based metagenetic analysis
of fecal microbiota was performed. In vitro gastrointestinal digestions
were performed in order to study the effect of chicory intestinal
digests on gut hormone regulation in enteroendocrine cells. Firmicutes/Bacteroidetes
ratio and gut bacterial groups, such as Alloprevotella, Blautia, Alistipes, and Oscillibacter, were found to be modulated by chicory. On
the other hand, CCK and GLP-1 satiety hormones were demonstrated to
be significantly increased by chicory in vitro.
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Fouré, Marion; Dugardin, Camille; Foligné, Benoît; Hance, Philippe; Cadalen, Thierry; Delcourt, Abigael; et al. (2018). Chicory Roots for Prebiotics and Appetite Regulation:
A Pilot Study in Mice. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.8b01055
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AUTHORS (12)
MF
Marion Fouré
CD
Camille Dugardin
BF
Benoît Foligné
PH
Philippe Hance
TC
Thierry Cadalen
AD
Abigael Delcourt
BT
Bernard Taminiau
GD
Georges Daube
RR
Rozenn Ravallec
BC
Benoit Cudennec
JH
Jean-Louis Hilbert
AL
Anca Lucau-Danila