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Chicory Roots for Prebiotics and Appetite Regulation: A Pilot Study in Mice

Version 2 2018-06-13, 13:51
Version 1 2018-06-12, 17:53
Posted on 2018-06-13 - 13:51
The objectives of this work are to address the prebiotic effects of chicory (Cichorium intybus) together with its possible role in appetite control. We compared nine chicory genotypes in order to determine if variations in the content of metabolites in the roasted roots would lead to modifications in release of satiety hormones and in composition of gut microbiota. To this aim, a 5-week dietary-intervention study was achieved using mice fed with distinct chicory-based preparations. A 16S rRNA gene-based metagenetic analysis of fecal microbiota was performed. In vitro gastrointestinal digestions were performed in order to study the effect of chicory intestinal digests on gut hormone regulation in enteroendocrine cells. Firmicutes/Bacteroidetes ratio and gut bacterial groups, such as Alloprevotella, Blautia, Alistipes, and Oscillibacter, were found to be modulated by chicory. On the other hand, CCK and GLP-1 satiety hormones were demonstrated to be significantly increased by chicory in vitro.

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Journal of Agricultural and Food Chemistry

AUTHORS (12)

Marion Fouré
Camille Dugardin
Benoît Foligné
Philippe Hance
Thierry Cadalen
Abigael Delcourt
Bernard Taminiau
Georges Daube
Rozenn Ravallec
Benoit Cudennec
Jean-Louis Hilbert
Anca Lucau-Danila
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