Chemical Ligand Space of Cereblon

Published on 2018-09-14T13:39:23Z (GMT) by
The protein cereblon serves as a substrate receptor of a ubiquitin ligase complex that can be tuned toward different target proteins by cereblon-binding agents. This approach to targeted protein degradation is exploited in different clinical settings and has sparked the development of a growing number of thalidomide derivatives. Here, we probe the chemical space of cereblon binding beyond such derivatives and work out a simple set of chemical requirements, delineating the metaclass of cereblon effectors. We report co-crystal structures for a diverse set of compounds, including commonly used pharmaceuticals, but also find that already minimalistic cereblon-binding moieties might exert teratogenic effects in zebrafish. Our results may guide the design of a post-thalidomide generation of therapeutic cereblon effectors and provide a framework for the circumvention of unintended cereblon binding by negative design for future pharmaceuticals.

Cite this collection

Boichenko, Iuliia; Bär, Kerstin; Deiss, Silvia; Heim, Christopher; Albrecht, Reinhard; N. Lupas, Andrei; et al. (2018): Chemical Ligand Space of Cereblon. ACS Publications. Collection.