Biodegradable π‑Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics

Published on 2019-11-08T22:43:31Z (GMT) by
We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show a high photothermal conversion efficiency (PCE) up to 82%, surpassing those of reported inorganic and organic PTT agents. In addition, the oligomer nanoparticles show excellent photostability and good biodegradability. The F8-PEG NPs are also demonstrated to have excellent biosafety and PTT efficacy both <i>in vitro</i> and <i>in vivo</i>. This contribution not only proposes a promising oligomer-based PTT agent but also provides insight into developing highly efficient nanomaterials for cancer theranostics.

Cite this collection

Li, Xiaozhen; Liu, Lu; Li, Shengliang; Wan, Yingpeng; Chen, Jia-Xiong; Tian, Shuang; et al. (2019): Biodegradable π‑Conjugated Oligomer Nanoparticles

with High Photothermal Conversion Efficiency for Cancer Theranostics. ACS Publications. Collection. https://doi.org/10.1021/acsnano.9b05383