Antifreeze
Protein Mimetic Metallohelices with Potent
Ice Recrystallization Inhibition Activity
Version 2 2017-08-17, 21:18
Version 1 2017-07-18, 13:12
Posted on 2017-08-17 - 21:18
Antifreeze
proteins are produced by extremophile species
to control ice formation and growth, and they have potential applications
in many fields. There are few examples of synthetic materials which
can reproduce their potent ice recrystallization inhibition property.
We report that self-assembled enantiomerically pure, amphipathic
metallohelicies inhibited ice growth at just 20 μM. Structure–property
relationships and calculations support the hypothesis that amphipathicity
is the key motif for activity. This opens up a new field of metallo-organic
antifreeze protein mimetics and provides insight into the origins
of ice-growth inhibition.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Mitchell, Daniel
E.; Clarkson, Guy; Fox, David J.; Vipond, Rebecca A.; Scott, Peter; Gibson, Matthew I. (2017). Antifreeze
Protein Mimetic Metallohelices with Potent
Ice Recrystallization Inhibition Activity. ACS Publications. Collection. https://doi.org/10.1021/jacs.7b05822
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (6)
DM
Daniel
E. Mitchell
GC
Guy Clarkson
DF
David J. Fox
RV
Rebecca A. Vipond
PS
Peter Scott
MG
Matthew I. Gibson
KEYWORDS
ice-growth inhibitionice recrystallization inhibition property20 μ Mself-assembled enantiomericallyice growthAntifreeze Protein Mimetic Metallohelicescontrol ice formationamphiPotent Ice Recrystallization Inhibition Activity Antifreeze proteinsmetallo-organic antifreeze protein mimeticscalculations support