Anti-inflammatory and α‑Glucosidase Inhibitory Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes of <i>Amomum villosum</i>

Published on 2019-11-08T19:47:52Z (GMT) by
A new tetranorditerpenoid (<b>1</b>), two new labdane diterpenoids (<b>2</b>, <b>3</b>), and nine known analogues (<b>4</b>–1<b>2</b>) were isolated from the rhizomes of <i>Amomum villosum</i> var. <i>xanthioides</i>. Compound <b>1</b> is an unprecedented rearranged tetranorlabdane diterpenoid, featuring a 6/6/5 fused tricarbocyclic skeleton with an α,β-unsaturated cyclopentenone unit, while <b>2</b> is a structurally rare labdane diterpenoid carrying a five-membered cyclic anhydride moiety. Their structures and absolute configurations were established on the basis of spectroscopic data and the experimental and calculated ECD data. Compound <b>4</b> showed inhibitory activity against nitric oxide production, with an IC<sub>50</sub> value of 2.4 μM, and also inhibited α-glucosidase activity (IC<sub>50</sub> = 10.0 μM).

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Yin, Hong; Dan, Wen-Jia; Fan, Bo-Yi; Guo, Chao; Wu, Kui; Li, Ding; et al. (2019): Anti-inflammatory and α‑Glucosidase Inhibitory

Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes

of Amomum villosum. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.9b00283