Anti-inflammatory and α‑Glucosidase Inhibitory
Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes
of Amomum villosum
Posted on 2019-11-08 - 19:47
A new tetranorditerpenoid (1), two new labdane diterpenoids
(2, 3), and nine known analogues (4–12) were isolated from the rhizomes
of Amomum villosum var. xanthioides. Compound 1 is an unprecedented rearranged tetranorlabdane
diterpenoid, featuring a 6/6/5 fused tricarbocyclic skeleton with
an α,β-unsaturated cyclopentenone unit, while 2 is a structurally rare labdane diterpenoid carrying a five-membered
cyclic anhydride moiety. Their structures and absolute configurations
were established on the basis of spectroscopic data and the experimental
and calculated ECD data. Compound 4 showed inhibitory
activity against nitric oxide production, with an IC50 value
of 2.4 μM, and also inhibited α-glucosidase activity (IC50 = 10.0 μM).
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Yin, Hong; Dan, Wen-Jia; Fan, Bo-Yi; Guo, Chao; Wu, Kui; Li, Ding; et al. (2019). Anti-inflammatory and α‑Glucosidase Inhibitory
Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes
of Amomum villosum. ACS Publications. Collection. https://doi.org/10.1021/acs.jnatprod.9b00283
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AUTHORS (9)
HY
Hong Yin
WD
Wen-Jia Dan
BF
Bo-Yi Fan
CG
Chao Guo
KW
Kui Wu
DL
Ding Li
KX
Kui-Feng Xian
GP
Gennaro Pescitelli
JG
Jin-Ming Gao
KEYWORDS
labdane diterpenoidECD dataIC 50α- glucosidase activityAmomum villosumnitric oxide productionAmomum villosum varspectroscopic dataNorlabdane Diterpenoids10.0 μ Mfive-membered cyclic anhydride moietytricarbocyclic skeletonIC 50 valuetetranorlabdane diterpenoid2.4 μ Mlabdane diterpenoidsCompound 1Compound 4cyclopentenone unit