Anisotropic pH-Responsive Hydrogels Containing Soft
or Hard Rod-Like Particles Assembled Using Low Shear
Version 2 2017-06-23, 04:29
Version 1 2017-03-01, 13:21
Posted on 2017-06-23 - 04:29
A simple
and versatile low-shear approach for assembling hydrogels
containing aligned rod-like particles (RLPs) that are birefringent
and exhibit pH-triggered anisotropic swelling is developed. Anisotropic
composite hydrogels are prepared by applying low shear (0.1 s–1) to mixtures of pH-responsive nanogels (NGs) and
RLPs. The NGs, which contained high methacrylic acid contents, acted
as both shear transfer vehicles and macro-cross-linkers for anisotropic
gel formation. Three model RLP systems are investigated: (i) soft
triblock copolymer worms, (ii) stiff self-assembled β-sheet
peptide fibers, and (iii) ultrahigh modulus nanocrystalline cellulose
fibers. RLP alignment was confirmed using polarized light imaging,
atomic force microscopy, and small-angle X-ray scattering as well
as modulus and anisotropic swelling experiments. Unexpectedly, the
composite gel containing the soft copolymer worms showed the most
pronounced anisotropy swelling. The copolymer worms enabled higher
RLP loadings than was possible for the stiffer RLPs. For fixed RLP
loading, the extent of anisotropic swelling increased with intra-RLP
bonding strength. The facile and versatile approach to anisotropic
gel construction demonstrated herein is expected to enable new applications
for strain sensing or biomaterials for soft tissue repair.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Milani, Amir H.; Fielding, Lee A.; Greensmith, Polly; Saunders, Brian R.; Adlam, Daman J.; J. Freemont, Anthony; et al. (2017). Anisotropic pH-Responsive Hydrogels Containing Soft
or Hard Rod-Like Particles Assembled Using Low Shear. ACS Publications. Collection. https://doi.org/10.1021/acs.chemmater.7b00110
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (13)
AM
Amir H. Milani
LF
Lee A. Fielding
PG
Polly Greensmith
BS
Brian R. Saunders
DA
Daman J. Adlam
AJ
Anthony J. Freemont
JH
Judith A. Hoyland
NW
Nigel W. Hodson
ME
Mohamed A. Elsawy
AM
Aline F. Miller
LP
Liam P. D. Ratcliffe
OM
Oleksandr O. Mykhaylyk
SA
Steven P. Armes
KEYWORDS
methacrylic acid contentstriblock copolymer wormsshear transfer vehiclesanisotropic gel constructionexhibit pH-triggered anisotropicNGultrahigh modulus nanocrystalline cellulose fiberscopolymer wormsHard Rod-Like Particles AssembledAnisotropic pH-Responsive Hydrogels Containinganisotropic gel formationself-assembled β- sheet peptide fibersmodel RLP systems