An Oxidative Dearomatization Approach To Prepare the Pentacyclic Core of Ryanodol

Published on 2018-06-13T13:55:44Z (GMT) by
An approach to synthesize the pentacyclic framework of the polyol diterpenoid ryanodol is reported. The ABC tricycle was constructed by a Co-mediated Pauson–Khand reaction, and both radical and anionic cyclization pathways were developed to form the E-ring. In addition, a reaction sequence involving SeO<sub>2</sub>-mediated enone oxidation and hydroxyl-directed oxy-Michael addition was developed to introduce the A-ring oxidation. The feasibility of forming the bridging D-ring by an oxidative dearomatization was established.

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Xu, Chen; Han, Arthur; Reisman, Sarah E. (2018): An Oxidative Dearomatization Approach To Prepare the

Pentacyclic Core of Ryanodol. ACS Publications. Collection.