A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site

Published on 2018-05-15T12:00:00Z (GMT) by
<div>Background:<p>A four-site RCT of <i>Fatigue: Take Control</i> (FTC), a multicomponent group program, found no significant differences from a control program, <i>MS: Take Control</i> (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months.</p>Objective:<p>Assess FTC for a delayed effect on fatigue.</p>Methods:<p>Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months.</p>Results:<p>Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC −8.9 (confidence interval (CI): 32.2, 45), MSTC −2.5 (CI 39.6, 47.7), <i>p</i> = 0.03) at 12 months.</p>Conclusion:<p>The delayed effect of FTC on fatigue suggests the need for longer follow-up when assessing interventions for fatigue.</p></div>

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Hugos, Cinda L; Cameron, Michelle H; Chen, Zunqiu; Chen, Yiyi; Bourdette, Dennis (2018): A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site. SAGE Journals. Collection.