A Ruthenium−Dihydrogen Putative Intermediate in Ketone Hydrogenation

Bergens, Steven H.

A Ruthenium−Dihydrogen Putative Intermediate in Ketone Hydrogenation

Posted on 2005-03-30 - 00:00

The compound fac-[Ru((R)-BINAP)(H)(2-PrOH)₃]⁺ (6) (BINAP = 2,2‘-bis(diphenylphosphino)-1,1‘-binaphthyl) reacts with (R,R)-dpen (dpen = 1,2-diphenylethylenediamine) under H₂ at −60 °C in 2-PrOH-d₈/CD₂Cl₂ to generate the cationic dihydrogen putative intermediate trans-[Ru((R)-BINAP)(H)(η²-H₂)((R,R)-dpen)]⁺ (2‘) without H−D exchange between the hydrogen ligands and the solvent. A ¹H NMR study concludes that the dihydrogen ligand in 2‘ does not protonate 2-PrOH to a catalytically significant extent, and that 2‘ requires an added base or hydride source to be an active catalyst.

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Hamilton, Robin J.; Leong, Carolyn G.; Bigam, Glen; Miskolzie, Mark; Bergens, Steven H. (2016). A Ruthenium−Dihydrogen Putative Intermediate in Ketone Hydrogenation. ACS Publications. Collection. https://doi.org/10.1021/ja043339k

https://doi.org/10.1021/ja043339k

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