A Regioselective Approach to Trisubstituted Pyrazoles
via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines
Posted on 2017-06-22 - 17:20
A palladium-catalyzed
oxidative carbonylation of arylhydrazines
and alkynes with balloon pressure CO/O2 to afford trisubstituted
pyrazoles in a one-pot manner has been developed. The formation of
trisubstituted pyrazoles involves a sequential C–N bond cleavage,
carbonylation, Sonogashira coupling, Michael addition, and intramolecular
condensation cyclization tandem process. An unprecedented oxidative
Sonogashira-carbonylation reaction of arylhydrazine plays a key role
for such a facile approach to pyrazoles.
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Tu, Yongliang; Zhang, Zhenming; Wang, Tao; Ke, Jiamei; Zhao, Junfeng (2017). A Regioselective Approach to Trisubstituted Pyrazoles
via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b01447
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AUTHORS (5)
YT
Yongliang Tu
ZZ
Zhenming Zhang
TW
Tao Wang
JK
Jiamei Ke
JZ
Junfeng Zhao