A Novel Synthetic Route to 3-Sulfenyl- and 3-Selenylindoles by n-Bu4NI-Induced Electrophilic Cyclization

Larock, Richard C.

A Novel Synthetic Route to 3-Sulfenyl- and 3-Selenylindoles by n-Bu₄NI-Induced Electrophilic Cyclization

Posted on 2009-01-01 - 00:00

3-Sulfenyl- and 3-selenylindoles are prepared in excellent yields by the palladium/copper-catalyzed crossing coupling of N,N-dialkyl-o-iodoanilines and terminal alkynes, followed by electrophilic cyclization with arylsulfenyl chlorides and arylselenyl chlorides in the presence of a stoichiometric amount of n-Bu₄NI.

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Chen, Yu; Cho, Chul-Hee; Larock, Richard C. (2016). A Novel Synthetic Route to 3-Sulfenyl- and 3-Selenylindoles by n-Bu₄NI-Induced Electrophilic Cyclization. ACS Publications. Collection. https://doi.org/10.1021/ol8021287

https://doi.org/10.1021/ol8021287

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