A Mild
Hydroaminoalkylation of Conjugated Dienes Using
a Unified Cobalt and Photoredox Catalytic System
Posted on 2017-10-19 - 19:16
Metallo-photoredox
catalysis has redefined the available bond disconnections
in the synthetic arsenal. By harnessing the one-electron chemistry
of photoredox catalysis in tandem with low-valent cobalt catalysts,
new methods by which functionalities may be stitched together become
available. Herein we describe the coupling of photoredox-generated
α-amino radical species with conjugated dienes using a unified
cobalt and iridium catalytic system in order to access a variety of
useful homoallylic amines from simple commercially available starting
materials. We present a series of mechanistic experiments that support
the intervention of Co–hydride intermediates that undergo diene
insertion to generate Co−π-allyl species.
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Thullen, Scott
M.; Rovis, Tomislav (2017). A Mild
Hydroaminoalkylation of Conjugated Dienes Using
a Unified Cobalt and Photoredox Catalytic System. ACS Publications. Collection. https://doi.org/10.1021/jacs.7b09252
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AUTHORS (2)
ST
Scott
M. Thullen
TR
Tomislav Rovis
KEYWORDS
Photoredox Catalytic System Metallo-photoredox catalysisarsenalConjugated Dienesone-electron chemistryspeciesinterventionaccessvarietybond disconnectionsiridiumexperimenthomoallylic aminesseriesmethodUnified CobaltmaterialfunctionalitietandemintermediateMild Hydroaminoalkylationdiene insertionphotoredox catalysislow-valent cobalt catalystsHereinphotoredox-generated α-