A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4

Matzuk, Martin M.

A Mild, DNA-Compatible Nitro Reduction Using B₂(OH)₄

Posted on 2019-03-13 - 17:41

A hypodiboric acid system for the reduction of nitro groups on DNA–chemical conjugates has been developed. This transformation provided good to excellent yields of the reduced amine product for a variety of functionalized aromatic, heterocyclic, and aliphatic nitro compounds. DNA tolerance to reaction conditions, extension to decigram scale reductions, successful use in a DNA-encoded chemical library synthesis, and subsequent target selection are also described.

CITE THIS COLLECTION

Du, Huang-Chi; Simmons, Nicholas; Faver, John C.; Yu, Zhifeng; Palaniappan, Murugesan; Riehle, Kevin; et al. (2019). A Mild, DNA-Compatible Nitro Reduction Using B₂(OH)₄. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.9b00497

https://doi.org/10.1021/acs.orglett.9b00497

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