A General Strategy for the Construction of Functionalized
Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki
Coupling
Posted on 2017-06-26 - 23:29
The preparation of substituted azaindolines
utilizing a domino
palladium-catalyzed Heck cyclization/Suzuki coupling is described.
The approach is amenable for the construction of all four azaindoline
isomers. A range of functional groups such as esters, amides, ketones,
sulfones, amines, and nitriles are all tolerated under the reaction
conditions.
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Schempp, Tabitha
T.; Daniels, Blake E.; Staben, Steven T.; Stivala, Craig E. (2017). A General Strategy for the Construction of Functionalized
Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki
Coupling. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.7b01606
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AUTHORS (4)
TS
Tabitha
T. Schempp
BD
Blake E. Daniels
SS
Steven T. Staben
CS
Craig E. Stivala