A Free-Radical-Promoted Site-Specific Cross-Dehydrogenative-Coupling
of N‑Heterocycles with Fluorinated Alcohols

Liu, Zhong-Quan

A Free-Radical-Promoted Site-Specific Cross-Dehydrogenative-Coupling of N‑Heterocycles with Fluorinated Alcohols

Version 2 2016-09-12, 20:25

Version 1 2016-08-26, 20:13

Posted on 2016-08-26 - 00:00

A C–C formation of an electron-rich N-heterocycle with fluorinated alcohol is developed. Through this radical-triggered cross-dehydrogenative coupling strategy, a wide range of useful building blocks such as C3 hydroxyfluoroalkylated indoles and pyrroles can be site-specifically synthesized. Mechanistic studies indicate a single-electron-transfer initiated radical cycle would be involved.

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Xu, Zhengbao; Hang, Zhaojia; Chai, Li; Liu, Zhong-Quan (2016). A Free-Radical-Promoted Site-Specific Cross-Dehydrogenative-Coupling of N‑Heterocycles with Fluorinated Alcohols. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.6b02274

https://doi.org/10.1021/acs.orglett.6b02274

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