4‑Cyanoindole-2′-deoxyribonucleoside
(4CIN): A Universal Fluorescent Nucleoside Analogue
Version 2 2018-07-11, 18:49
Version 1 2018-07-10, 19:45
Posted on 2018-07-11 - 18:49
The synthesis and
characterization of a universal and fluorescent
nucleoside, 4-cyanoindole-2′-deoxyribonucleoside (4CIN), and its incorporation into DNA is described. 4CIN is a highly efficient fluorophore with quantum yields >0.90 in
water.
When incorporated into duplex DNA, 4CIN pairs equivalently
with native nucleobases and has uniquely high quantum yields ranging
from 0.15 to 0.31 depending on sequence and hybridization contexts,
surpassing that of 2-aminopurine, the prototypical nucleoside fluorophore. 4CIN constitutes a new isomorphic nucleoside for diverse applications.
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Passow, Kellan
T.; Harki, Daniel A. (2018). 4‑Cyanoindole-2′-deoxyribonucleoside
(4CIN): A Universal Fluorescent Nucleoside Analogue. ACS Publications. Collection. https://doi.org/10.1021/acs.orglett.8b01746
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