John Hildyard

Publications

• Identification of qPCR reference genes suitable for normalising gene expression in the developing mouse embryo [version 1; peer review: 1 approved]
• Rapid histological quantification of muscle fibrosis and lysosomal activity using the HSB colour space
• Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.
• Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy.
• How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse.
• Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).
• Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.
• Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?
• Diauxic shift-dependent relocalization of decapping activators Dhh1 and Pat1 to polysomal complexes.
• Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis.
• Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier.
• Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.
• Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo
• Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy
• Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics
• Identification of qPCR reference genes suitable for normalising gene expression in the developing mouse embryo
• Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy
• Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy
• Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo [version 2; peer review: 2 approved]
• Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics
• Identification of quantitative polymerase chain reaction reference genes suitable for normalising gene expression in the brain of normal and dystrophic mice and dogs [version 1; peer review: 1 approved with reservations]
• Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy [version 2; peer review: 2 approved]
• Identification of qPCR reference genes suitable for normalising gene expression in the developing mouse embryo [version 2; peer review: 2 approved, 1 approved with reservations]
• The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy [version 1; peer review: awaiting peer review]
• Identification of qPCR reference genes suitable for normalising gene expression in the developing mouse embryo [version 2; peer review: 3 approved]
• Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy
• The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy [version 1; peer review: 1 approved]
• Dystrophin myonuclear domain restoration governs treatment efficacy in dystrophic muscle
• The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy [version 1; peer review: 2 approved]
• Identification of quantitative polymerase chain reaction reference genes suitable for normalising gene expression in the brain of normal and dystrophic mice and dogs [version 1; peer review: 1 approved, 1 approved with reservations]
• Identification of quantitative polymerase chain reaction reference genes suitable for normalising gene expression in the brain of normal and dystrophic mice and dogs [version 2; peer review: 1 approved, 1 approved with reservations]
• When Size Really Matters: The Eccentricities of Dystrophin Transcription and the Hazards of Quantifying mRNA from Very Long Genes
• When Size Really Matters: The Eccentricities of Dystrophin Transcription and the Hazards of Quantifying mRNA from Very Long Genes
• Identification of quantitative polymerase chain reaction reference genes suitable for normalising gene expression in the brain of normal and dystrophic mice and dogs [version 2; peer review: 2 approved, 1 approved with reservations]
• Longitudinal assessment of skeletal muscle functional mechanics in the DE50-MD dog model of Duchenne Muscular Dystrophy
• Longitudinal assessment of skeletal muscle functional mechanics in the DE50-MD dog model of Duchenne muscular dystrophy
• Histological image quantification of picrosirius red stained skeletal muscle sections