Wenfei Sun

Publications

• Myoglobin-mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans.
• Identification of a regulatory pathway inhibiting adipogenesis via RSPO2.
• Local acetate inhibits brown adipose tissue function.
• GPR180 is a component of TGF beta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1
• Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis.
• Analysis of Single-Cell/Nucleus Transcriptome Data in Adipose Tissue.
• Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle
• Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory
• Fat for heat.
• A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice.
• Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
• Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue.
• Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa.
• Plasticity and heterogeneity of thermogenic adipose tissue
• Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
• snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
• Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.
• Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity, confirming the gene's candidacy in 6q16.1 deletions.
• Environmental and Nutritional Effects Regulating Adipose Tissue Function and Metabolism Across Generations
• BATLAS: Deconvoluting Brown Adipose Tissue
• Metabolic reconstitution of germ-free mice by a gnotobiotic microbiota varies over the circadian cycle.
• Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots
• Temporal trajectories of human brown and white adipocyte progenitors at single cell resolution
• The obesity-linked human lncRNA AATBC regulates adipocyte plasticity by stimulating mitochondrial dynamics and respiration
• Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice
• Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy men.
• The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes.
• Alternative Splicing of Latrophilin-3 Controls Synapse Formation
• Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
• Fat cells with a sweet tooth
• Dietary ratios of n-6/n-3 polyunsaturated fatty acids during maternal pregnancy affect hippocampal neurogenesis and apoptosis in mouse offspring
• Bmp4 Promotes a Brown to White-like Adipocyte Shift
• Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase
• A stromal cell population that inhibits adipogenesis in mammalian fat depots
• Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
• Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs
• Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice
• Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity
• ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation
• A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
• Quantification of adipocyte numbers following adipose tissue remodeling
• Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation.
• Laminin α4 Expression in Human Adipose Tissue Depots and Its Association with Obesity and Obesity Related Traits.
• Single-cell RNA sequencing identifies MFSD2B in megakaryocyte progenitors as a regulator of vascular senescence
• Alternative splicing of latrophilin-3 controls synapse formation
• Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory
• Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape.
• The cortical amygdala consolidates a socially transmitted long-term memory
• Blood methylation pattern reflects epigenetic remodelling in adipose tissue after bariatric surgery.
• Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.
• Expression of Intelectin-1, also known as Omentin-1, is related to clinical phenotypes such as overweight, obesity, insulin resistance, and changes after bariatric surgery.
• Adipose tissue retains an epigenetic memory of obesity after weight loss
• Unveiling adipose populations linked to metabolic health in obesity.