Vesa Oikonen

Publications

• Pancreatic Metabolism, Blood Flow and β-Cell Function in Obese Humans. PMID: 24527718
• Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity. DOI: 10.1007/s00125-012-2825-5
• Correlation of 18F-FDG PET/CT assessments with disease activity and markers of inflammation in patients with early rheumatoid arthritis following the initiation of combination therapy with triple oral antirheumatic drugs. DOI: 10.1007/s00259-012-2282-x
• Pulmonary blood flow and its distribution in highly trained endurance athletes and healthy control subjects. DOI: 10.1152/japplphysiol.00710.2012
• Noninvasive parametric blood flow imaging of head and neck tumours using [15O]H2O and PET/CT. DOI: 10.1097/MNM.0b013e3283579e6e
• The effect of revascularization of renal artery stenosis on renal perfusion in patients with atherosclerotic renovascular disease. DOI: 10.1093/ndt/gfs301
• Cross-validation of input functions obtained by H₂ 15O PET imaging of rat heart and a blood flow-through detector. DOI: 10.1007/s11307-011-0511-5
• Evaluation of 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs. DOI: 10.1016/j.nucmedbio.2011.11.007
• Extraction of input function from rat [18F]FDG PET images. DOI: 10.1007/s11307-010-0449-z
• Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment. DOI: 10.1177/1352458511399613
• Different metabolic responses of human brown adipose tissue to activation by cold and insulin. DOI: 10.1016/j.cmet.2011.06.012
• Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities. DOI: 10.1152/ajpendo.00680.2010
• Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition. DOI: 10.1152/ajpheart.00996.2010
• PET imaging of blood flow and glucose metabolism in localized musculoskeletal tumors of the extremities. DOI: 10.1016/j.nucmedbio.2010.08.012
• Reproducibility of striatal and thalamic dopamine D2 receptor binding using [11C]raclopride with high-resolution positron emission tomography. DOI: 10.1038/jcbfm.2010.64
• Cholinergic dysfunction after traumatic brain injury: Preliminary findings from a PET study ISSN: 0028-3878
• Increased brain fatty acid uptake in metabolic syndrome. DOI: 10.2337/db09-0138
• Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia. DOI: 10.1152/ajpregu.00056.2010
• Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity. DOI: 10.1152/japplphysiol.00745.2009
• Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301. DOI: 10.1038/clpt.2008.241
• Parametric renal blood flow imaging using [15O]H2O and PET. DOI: 10.1007/s00259-008-0994-8
• Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography. DOI: 10.1007/s00259-008-1000-1
• Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects. DOI: 10.1007/s00259-008-0935-6
• The effects of xenon anesthesia on the relationship between cerebral glucose metabolism and blood flow in healthy subjects: a positron emission tomography study. DOI: 10.1213/ane.0b013e31818ffc9d
• Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men. DOI: 10.1113/jphysiol.2008.158113
• Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects. DOI: 10.1016/j.neuroimage.2008.02.035
• Quantification of liver perfusion with [(15)O]H(2)O-PET and its relationship with glucose metabolism and substrate levels. DOI: 10.1016/j.jhep.2008.01.029
• Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility. DOI: 10.1038/sj.jcbfm.9600607
• Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease. DOI: 10.1002/ana.21212
• Xenon does not affect gamma-aminobutyric acid type A receptor binding in humans. DOI: 10.1213/01.ane.0000287658.14763.13
• P2-093: The effects of the E4 allele of apolipoprotein E and the K variant of butyrylcholinesterase on cerebral butyrylcholinesterase activity in patients with Alzheimer's disease DOI: 10.1016/j.jalz.2008.05.1166
• Effects of xenon anesthesia on cerebral blood flow in humans: a positron emission tomography study. DOI: 10.1097/01.anes.0000267596.57497.92
• Simultaneous evaluation of myocardial blood flow, cardiac function and lung water content using [15O]H2O and positron emission tomography. DOI: 10.1007/s00259-006-0259-3
• Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region. DOI: 10.1038/sj.jcbfm.9600326
• Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET. DOI: 10.1007/s00259-006-0154-y
• Voxel-based NK1 receptor occupancy measurements with [(18)F]SPA-RQ and positron emission tomography: a procedure for assessing errors from image reconstruction and physiological modeling. DOI: 10.1007/s11307-007-0096-1
• Non-Invasive Estimation of Subcutaneous and Visceral Adipose Tissue Blood Flow by Using [15O]H2O PET with Image Derived Input Functions DOI: 10.2174/1874347100701010007
• 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study. PMID: 16741312
• Comparison of MRI and positron emission tomography for measuring myocardial perfusion reserve in healthy humans. DOI: 10.1002/mrm.20833
• Motion detection and correction for dynamic ( 15)O-water myocardial perfusion PET studies. DOI: 10.1007/s00259-005-1846-4
• Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing. DOI: 10.1038/sj.npp.1300790
• High intensity exercise decreases global brain glucose uptake in humans. DOI: 10.1113/jphysiol.2005.091355
• S-ketamine anesthesia increases cerebral blood flow in excess of the metabolic needs in humans. DOI: 10.1097/00000542-200508000-00008
• Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain. DOI: 10.1007/s11307-005-7001-6
• Visualization and Quantification of Neurokinin-1 (NK1) Receptors in the Human Brain DOI: 10.1007/s11307-005-0001-8
• Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans. DOI: 10.1213/01.ANE.0000135409.81842.31
• Effect of training status on regional disposal of circulating free fatty acids in the liver and skeletal muscle during physiological hyperinsulinemia. PMID: 15333480
• Defective liver disposal of free fatty acids in patients with impaired glucose tolerance. DOI: 10.1210/jc.2003-031142
• Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer. DOI: 10.1016/j.ijrobp.2003.12.014
• Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects. DOI: 10.1016/j.pain.2004.01.013
• Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans. DOI: 10.1097/00000542-200405000-00006
• Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride. DOI: 10.1097/00006231-200312000-00002
• Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. DOI: 10.1097/00000542-200309000-00015
• Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans. DOI: 10.1097/00000542-200309000-00016
• Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET. DOI: 10.1007/s00259-003-1215-0
• Effects of metformin and rosiglitazone monotherapy on insulin-mediated hepatic glucose uptake and their relation to visceral fat in type 2 diabetes. PMID: 12832315
• Insulin stimulates liver glucose uptake in humans: an 18F-FDG PET Study. PMID: 12732668
• Insulin-mediated hepatic glucose uptake is impaired in type 2 diabetes: evidence for a relationship with glycemic control. DOI: 10.1210/jc.2002-021446
• Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men. DOI: 10.1038/oby.2003.39
• Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease. DOI: 10.1136/jnnp.74.1.113
• Quantifying tumour hypoxia with fluorine-18 fluoroerythronitroimidazole ([18F]FETNIM) and PET using the tumour to plasma ratio. DOI: 10.1007/s00259-002-1016-x
• 14(R,S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle. DOI: 10.1007/s00259-002-0979-y
• 18F-Fluoroerythronitroimidazole radiation dosimetry in cancer studies. PMID: 12468519
• Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease. DOI: 10.1097/00004714-200212000-00012
• Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. DOI: 10.1097/00000542-200206000-00015
• Evidence for spatial heterogeneity in insulin- and exercise-induced increases in glucose uptake: studies in normal subjects and patients with type 1 diabetes. DOI: 10.1210/jc.86.11.5525
• Imaging of blood flow and hypoxia in head and neck cancer: initial evaluation with [(15)O]H(2)O and [(18)F]fluoroerythronitroimidazole PET. PMID: 11696633
• Kinetic modeling of [(18)F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model. PMID: 11500308
• Enhanced oxygen extraction and reduced flow heterogeneity in exercising muscle in endurance-trained men. PMID: 11350784
• Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes. DOI: 10.2337/diabetes.50.6.1371
• Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data. DOI: 10.1007/s002590000458
• Detection of response to COMT inhibition in FDOPA PET in advanced Parkinson's disease requires prolonged imaging ISSN: 0887-4476
• Lumped constant for [(18)F]fluorodeoxyglucose in skeletal muscles of obese and nonobese humans. PMID: 11052968
• Measurement of extrastriatal D2-like receptor binding with [11C]FLB 457--a test-retest analysis. DOI: 10.1007/s002590000342
• Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography. DOI: 10.2337/diabetes.49.7.1084
• [11 C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology. PMID: 10881249
• Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease. PMID: 10751262
• Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone. PMID: 10647606
• Extrastriatal dopamine D2 and D3 receptors in early and advanced Parkinson's disease ISSN: 0028-3878
• Insulin and exercise stimulated glucose uptake and its heterogeneity in subjects with type 1 diabetes. In vivo studies using [15O]-H2O, [15O]-O2, [18F]-FDG and PET ISSN: 0168-8227
• Quantification of [Carbonyl-11C]WAY-100635 binding: considerations on the cerebellum ISSN: 0969-8051
• Myocardial blood flow, oxygen consumption, and fatty acid uptake in endurance athletes during insulin stimulation. PMID: 10516116
• Striatal uptake of a novel PET ligand, [18F]?-CFT, is reduced in early Parkinson's disease ISSN: 0887-4476
• Striatal uptake of a novel PET ligand, [18F]β‐CFT, is reduced in early Parkinson's disease ISSN: 0887-4476
• Free fatty acid uptake in the myocardium and skeletal muscle using fluorine-18-fluoro-6-thia-heptadecanoic acid. PMID: 9708500
• Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension. PMID: 9626175
• Striatal 6-[18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: differing response in relation to presynaptic dopaminergic dysfunction. DOI: 10.1002/(SICI)1098-2396(199712)27:4<336::AID-SYN7>3.0.CO;2-D
• [18F]fluorodopa PET shows striatal dopaminergic dysfunction in juvenile neuronal ceroid lipofuscinosis. PMID: 9219750
• Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET. PMID: 9025761
• A PET Study on the Acute Effect of Ethanol on Striatal D2 Dopamine Receptors with [11C]Raclopride in Healthy Males ISSN: 0885-6222
• Acute effects of celiprolol on muscle blood flow and insulin sensitivity: studies using [15O]-water, [18F]-fluorodeoxyglucose and positron emission tomography. DOI: 10.1007/s002280050243
• Striatal 6-[18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: Differing response in relation to presynaptic dopaminergic dysfunction ISSN: 0887-4476
• Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography. DOI: 10.2337/diab.45.11.1471
• PET studies on brain monoamine transporters with carbon-11-beta-CIT in Parkinson's disease. PMID: 7790953
• Striatal [18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease. DOI: 10.1007/BF02251225
• Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride ISSN: 0022-510X
• PET studies on dopamine D1 receptors in the human brain with carbon-11-SCH 39166 and carbon-11-NNC 756. PMID: 7989969
• Decrease in human striatal dopamine D2 receptor density with age: a PET study with [11C]raclopride. PMID: 8436624