Tomokazu Fukuda

Publications

• Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase.
• Rat-derived feeder cells immortalized by expression of mutant CDK4, cyclin D, and telomerase can support stem cell growth.
• Extended proliferation of chicken- and Okinawa rail-derived fibroblasts by expression of cell cycle regulators.
• Global transcriptome analysis of pig induced pluripotent stem cells derived from six and four reprogramming factors.
• Intestinal Bacteria as Powerful Trapping Lifeforms for the Elimination of Radioactive Cesium.
• Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing.
• Establishment of immortalized primary cell from the critically endangered Bonin flying fox (Pteropus pselaphon).
• Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions
• Expression of human cell cycle regulators in the primary cell line of the African savannah elephant (loxodonta africana) increases proliferation until senescence, but does not induce immortalization
• Generation of aminoterminally truncated, stable types of bioactive bovine and porcine fibroblast growth factor 4 in Escherichia coli
• Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice
• Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile
• Analysis of plasma protein concentrations and enzyme activities in cattle within the ex-evacuation zone of the Fukushima Daiichi Nuclear Plant Accident
• MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney
• The poly-cistronic expression of four transcriptional factors (CRX, RAX, NEURO-D, OTX2) in fibroblasts via retro- or lentivirus causes partial reprogramming into photoreceptor cells
• A comprehensive dose evaluation project concerning animals affected by the Fukushima Daiichi Nuclear Power Plant accident: Its set-up and progress
• Expression of Six Proteins Causes Reprogramming of Porcine Fibroblasts Into Induced Pluripotent Stem Cells With Both Active X Chromosomes
• 90Sr in teeth of cattle abandoned in evacuation zone: Record of pollution from the Fukushima-Daiichi Nuclear Power Plant accident
• Changes in estrogen receptor expression in the chick thymus during late embryonic development
• Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators
• Chick derived induced pluripotent stem cells by the poly-cistronic transposon with enhanced transcriptional activity
• Hexavalent chromium is cytotoxic and genotoxic to hawksbill sea turtle cells
• Software development for estimating the concentration of radioactive cesium in the skeletal muscles of cattle from blood samples
• Correction: Analysis of plasma protein concentrations and enzyme activities in cattle within the ex-evacuation zone of the Fukushima Daiichi nuclear plant accident
• Gene expression analyses of the small intestine of pigs in the ex-evacuation zone of the Fukushima Daiichi Nuclear Power Plant
• Induced pluripotent stem cells with six reprogramming factors from prairie vole, which is an animal model for social behaviors
• Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase
• Establishment of an immortalized cell line derived from the prairie vole via lentivirus-mediated transduction of mutant cyclin-dependent kinase 4, cyclin d, and telomerase reverse transcriptase
• miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway
• The Causal Relationship between DNA Damage Induction in Bovine Lymphocytes and the Fukushima Nuclear Power Plant Accident
• 90Sr specific activity of teeth of abandoned cattle after the Fukushima accident – teeth as an indicator of environmental pollution
• Estimation of concentration of radionuclides in skeletal muscle from blood, based on the data from abandoned animals in Fukushima
• Peroxisome proliferator-activated receptor α mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice
• Prolyl isomerase Pin1 regulates doxorubicin-inducible P-glycoprotein level by reducing Foxo3 stability
• Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions
• Electron probe X-ray microanalysis of boar and inobuta testes after the Fukushima accident
• Dietary intake of iodine-enriched eggs decreases the incidence of mouse mammary tumors caused by the activated ErbB2 oncogene
• Cesium radioactivity in peripheral blood is linearly correlated to that in skeletal muscle: Analyses of cattle within the evacuation zone of the Fukushima Daiichi Nuclear Power Plant
• Primary fibroblast cultures and karyotype analysis for the olive ridley sea turtle (Lepidochelys olivacea)
• Interaction between leptospiral lipopolysaccharide and toll-like receptor 2 in pig fibroblast cell line, and inhibitory effect of antibody against leptospiral lipopolysaccharide on interaction
• Generation of Oxtr cDNAHA-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner
• Immortalization of Fetal Bovine Colon Epithelial Cells by Expression of Human Cyclin D1, Mutant Cyclin Dependent Kinase 4, and Telomerase Reverse Transcriptase: An in Vitro Model for Bacterial Infection
• Transgenic expression of Telomerase reverse transcriptase (Tert) improves cell proliferation of primary cells and enhances reprogramming efficiency into the induced pluripotent stem cell
• Specific and spatial labeling of P0-Cre versus Wnt1-Cre in cranial neural crest in early mouse embryos
• Coffee consumption delays the hepatitis and suppresses the inflammation related gene expression in the Long-Evans Cinnamon rat
• Comparative cytotoxicity and genotoxicity of soluble and particulate hexavalent chromium in human and hawksbill sea turtle (Eretmochelys imbricata) skin cells
• Establishment of cell lines derived from the genus macaca through controlled expression of cell cycle regulators
• Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells
• Leptospiral lipopolysaccharide stimulates the expression of toll-like receptor 2 and cytokines in pig fibroblasts
• Correction to Conditional transgenic system for mouse Aurora A kinase: Degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein. [Mol Cell Biol, 25, 12, 2005, 5270-5281]
• TSC2 gene mutant (Eker) rat model of a mendelian dominantly inherited cancer
• A new Western blotting method using polymer immunocomplexes: Detection of Tsc1 and Tsc2 expression in various cultured cell lines
• Immunological characteristics and response to lipopolysaccharide of mouse lines selectively bred with natural and acquired immunities
• Efficient establishment of primary fibroblast cultures from the hawksbill sea turtle (Eretmochelys imbricata)
• Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of the simian vacuolating virus 40 large T fragment
• Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: Detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo
• Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats
• Shortened telomere length and increased telomerase activity in hamster pancreatic duct adenocarcinomas and cell lines
• Chemopreventive efficacy of piroxicam administered alone or in combination with lycopene and β-carotene on the development of rat urinary bladder carcinoma after N-butyl-N-(4-hydroxybutyl)nitrosamine treatment
• Prevention by Methionine of Enhancement of Hepatocarcinogenesis by Coadministration of a Choline‐deficient L‐Amino Acid‐defined Diet and Ethionine in Rats
• Effects of radioactive caesium on bull testes after the Fukushima nuclear plant accident
• The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain
• Increased telomerase activities in human pancreatic duct adenocarcinomas
• Common amino acid sequences deduced from coding exons of the porcine FGF4 gene in two breeds and production of the encoded protein in Escherichia coli
• BMP type I receptor inhibition reduces heterotopic ossification
• Distribution of Artificial Radionuclides in Abandoned Cattle in the Evacuation Zone of the Fukushima Daiichi Nuclear Power Plant
• Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells
• Erratum: BMP type I receptor inhibition reduces heterotopic ossification (Nature Medicine (2008) 14, (1363-1369))
• Localization of estrogen receptor in the central lymphoid organs of chickens during the late stage of embryogenesis
• A novel gene ″Niban″ upregulated in renal carcinogenesis: Cloning by the cDNA-amplified fragment length polymorphism approach
• Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient l-amino acid-defined diet and ethionine in rats
• Generation of Venus reporter knock-in mice revealed MAGI-2 expression patterns in adult mice
• Identification of stage-specific gene expression signatures in response to retinoic acid during the neural differentiation of mouse embryonic stem cells
• Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry
• Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells
• Effect of dietary addition of seaweed and licorice on the immune performance of pigs
• Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat
• Conditional transgenic system for mouse Aurora A kinase: Degradation by the ubiquitin proteasome pathway controls the level of the transgenic protein
• Anti-proliferative effect of an analogue of the LL-37 peptide in the colon cancer derived cell line HCT116 p53+/+and p53-/-
• Establishment of a reporter system to monitor silencing status in induced pluripotent stem cell lines
• Individual Variation of the Genetic Response to Bisphenol A in Human Foreskin Fibroblast Cells Derived from Cryptorchidism and Hypospadias Patients
• Oxygenomics in environmental stress
• Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse
• Expression of heregulin by mouse mammary tumor cells: Role in activation of ErbB receptors
• Shortened telomere length in hepatocellular carcinomas and corresponding background liver tissues of patients infected with hepatitis virus
• Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling
• Production of bioactive bovine fibroblast growth factor 4 in E.coli based on the common nucleotide sequence of its structural gene in three breeds
• Cloning of differentially expressed genes in highly and low metastatic rat osteosarcomas by a modified cDNA-AFLP method
• Infrequent somatic alteration of p16/MTS1 in human primary superficial bladder cancers
• Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2
• Generation of metastatic variants of Eker renal carcinoma cell lines for experimental investigation of renal cancer metastasis
• Multifocal micronodular pneumocyte hyperplasia and lymphangioleiomyomatosis in tuberous sclerosis with a TSC2 gene
• Identification of novel low-dose bisphenol A targets in human foreskin fibroblast cells derived from hypospadias patients