Teresa Cunha-Oliveira

Publications

• Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells
• Berberine-induced Cardioprotection and Sirt3 Modulation in Doxorubicin-treated H9c2 Cardiomyoblasts
• Single nanomolar doxorubicin exposure triggers compensatory mitochondrial responses in H9c2 cardiomyoblasts
• Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease
• Early mitochondrial changes associated with the toxicity of different drugs of abuse in differentiated SH-SY5Y cells
• Epigenetics in Doxorubicin Cardiotoxicity
• Glycolytic fluxes and metabolic profiles distinguish amyotrophic lateral sclerosis patients from healthy controls
• Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress
• Data mining analysis of respiratory and glycolytic fluxes from amyotrophic lateral sclerosis patients: Unraveling the effect of SOD1 mutation.
• Função mitocondrial e stress oxidativo no tecido adiposo epicardial de pacientes com doença cardíaca com ou sem diabetes.
• Impact of Rebaudioside A in the metabolism of breast cancer cells and assessment of its chemotherapeutic potential
• Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects
• Maternal obesity-induced oxidative damage impairs macroautophagy and unbalances mitochondrial dynamics
• Non-supervised analysis of neurotoxicity of mitochondrial poisons 6-OHDA and Rotenone.
• Doxorubicin persistently rewires cardiac circadian homeostasis in mice
• Early mitochondrial metabolism and dynamics changes as predictors of neurodegeneration and neuronal cell death
• Molecular and functional characterization of human skin fibroblasts in different metabolic contexts
• Human skin fibroblasts from sporadic Parkinson’s disease patients as a surrogate to measure the efficacy of novel mitochondria-directed antioxidant therapy
• Uncovering hidden patterns in biological datasets to identify metabolic alterations caused by acute and sub-chronic DOX treatments
• Adaptações na fosforilação oxidativa hepática provocadas pela obesidade durante a gravidez num modelo ovino
• Adaptações na fosforilação oxidativa hepática provocadas pela obesidade durante a gravidez num modelo ovino
• Função mitocondrial e stress oxidativo no tecido adiposo epicardial de pacientes com doença cardíaca com ou sem diabetes.
• IUGR Remodels Fetal Cardiac Left Ventricular Mitochondria in Baboons
• Maternal Obesity (MO) in an Ovine Model Results in Disruption of Offspring (F1) Mitochondrial Respirasomes.
• Intracellular and Intercellular Mitochondrial Dynamics in Parkinson's Disease
• Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention
• Data Extraction from Mitochondrial Motility Tracking using Computational Algorithms
• Exploratory analysis of mitochondrial metabolism in lymphoblasts from Amyotrophic Lateral Sclerosis patients to reveals discriminant biomarkers.
• Maternal Obesity (MO) in an Ovine Model Results in Disruption of Offspring (F1) Mitochondrial Respirasomes
• Differentiated SH-SY5Y cells as a cellular model to study mitochondrial physiology and dynamics
• Morphological and functional mitochondrial remodeling in human skin fibroblasts cultured with different metabolic fuels.
• Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes
• Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity
• In Vitro Methodologies to Investigate Drug-Induced Toxicities
• Mitochondrial Toxicity Induced by Chemotherapeutic Drugs
• Role of Mitochondria on the Neurological Effects of Cocaine
• Influence of SOD1 mutation on lymphoblast respiration and glycolytic rates from amyotrophic lateral sclerosis patients
• Comparative analysis of drugs of abuse toxicity in differentiated SH-SY5Y cells
• Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells
• Unraveling metabolic effects underlying acute cardiotoxicity of the antineoplastic drug Doxorubicin
• Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6-hydroxydopamine
• Mitochondrial and metabolic remodeling in human skin fibroblasts in response to glucose availability
• A Data Science Approach to Sub-chronic Doxorubicin Cardiotoxicity Reveals Hidden Patterns of Metabolic Remodeling
• Mitochondria as biosensors for disease staging and therapeutic response
• A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients
• Analysis of Proapoptotic Protein Trafficking to and from Mitochondria
• Maternal obesity in sheep impairs foetal hepatic mitochondrial respiratory chain capacity
• Refinement of a differentiation protocol using neuroblastoma SH-SY5Y cells for use in neurotoxicology research
• Cocaine as a Neurotoxin
• Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction
• Ketogenic diets: from cancer to mitochondrial diseases and beyond.
• Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.
• Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse
• Role of mtDNA-related mitoepigenetic phenomena in cancer.
• Drugs of abuse induce apoptotic features in PC12 cells
• Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria
• Acute effects of cocaine, morphine and their combination on bioenergetic function and susceptibility to oxidative stress of rat liver mitochondria
• Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells.
• Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
• Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship
• Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity
• Neuronal dysfunction induced by drugs of abuse- cellular and molecular approach (ISBN 9783639176698)
• Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition
• Neurotoxicity of heroin-cocaine combinations in rat cortical neurons
• BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons
• Medical Toxicology of Drugs of Abuse
• Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons
• Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells
• Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs
• Oxidative stress and drugs of abuse: An update
• β-adrenergic over-stimulation and cardio-myocyte apoptosis: Two receptors, one organelle, two fates?
• Neurotoxicidade induzida por drogas de abuso
• Neuronal dysfunction induced by drugs of abuse
• Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide
• Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF.
• Bioenergetic dysfunction in Huntington's disease human cybrids
• Analysis of pro-apoptotic protein trafficking to and from mitochondria
• Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice
• Neurotoxicity of cocaine
• Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease - Resemblance to the effect of amphetamine drugs of abuse
• Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathways
• Alucinogénios
• Efeito crónico da heroína e do peróxido de hidrogénio em células PC12
• Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington's Disease Human Lymphoblasts
• Cocaine as a neurotoxin
• Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells
• Quantitative analysis of neuronal mitochondrial movement reveals patterns resulting from neurotoxicity of rotenone and 6‐hydroxydopamine
• Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints
• Changes in gene expression in cells cultured in HGm or adapted to LGm or OXPHOSm - Correlations.
• Changes in gene expression in cells cultured in HGm or adapted to LGm or OXPHOSm - PCA
• Mitochondrial energy levels and network organization in NHDF cells cultured in HGm or adapted to OXPHOSm or to LGm.
• Mitochondrial metabolism and substrate preference.
• Changes in gene expression in cells cultured in HGm or adapted to LGm or OXPHOSm
• MPV17 mutations are associated with a quiescent energetic metabolic profile
• Metabolic remodeling upon up-regulation of oxidative phosphorylation in human skin fibroblasts as a tool for personalized medicine
• Oxidant/antioxidant imbalance in lymphoblasts from amyotrophic lateral sclerosis patients with SOD1 mutations and unknown mutations
• AntiOxCIN4 a new mitochondriotropic derivative based on the natural polyphenol caffeic acid reverts cellular and mitochondrial metabolic defects of fibroblasts from idiopathic Parkinson's Disease
• A novel phenolic acid-based mitochondria-targeted antioxidant improves cellular responses to oxidative stress in fibroblasts from sporadic Parkinson’s disease patients
• Evaluation of 6-Hydroxydopamine and Rotenone in Vitro Neurotoxicity in SH-SY5Y Cells using Computational Applied Statistics
• Manipulation of glucose availability promotes different in vitro redox environments in human dermal fibroblasts
• Multi-dimensional Analysis of Metabolic and Mitochondrial Dysfunction Parameters in Lymphoblasts from Amyotrophic Lateral Sclerosis Patients
• Oxidative Stress Profile in Lymphoblasts from Amyotrophic Lateral Sclerosis Patients with SOD1 Mutations and Unknown mutations
• Visualization of metabolic rewiring of NHDF cells in response to extracellular glucose concentration
• Good practices with experimental data
• UNRAVELING GLYCOLIC PATHWAYS ON AMYOTROPHIC LATERAL SCLEROSIS PATIENTS PRESENTING MUTANT SOD1 OR UNKNOWN MUTATIONS
• Oxidative stress profiles of lymphoblasts from Amyotrophic Lateral Sclerosis patients with or without known SOD1 Mutations
• Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics
• Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics
• Neurotoxicidade induzida por drogas de abuso
• Challenges in mitochondrial profiling during pre-clinical studies
• NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells
• Machine learning in the context of better healthcare in aging
• Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations
• Altered metabolism and oxidative stress in skin fibroblasts from Parkinson's disease patients
• Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity
• HSP90: A Key Player in Metal-Induced Carcinogenesis?
• Qual o efeito das drogas de abuso no cérebro?
• Estudo de genética populacional em STR's
• Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics
• Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems
• Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model
• Mitochondria: A Promising Convergent Target for the Treatment of Amyotrophic Lateral Sclerosis
• Best Practices for Data Management and Sharing in Experimental Biomedical Research
• Heterogeneous redox responses in NHDF cells primed to enhance mitochondrial bioenergetics
• Creating Physiological Cell Environments In Vitro: Adjusting Cell Culture Media Composition and Oxygen Levels to Investigate Mitochondrial Function and Cancer Metabolism
• Characterization of the Mitochondria Function and Metabolism in Skin Fibroblasts Using the Biolog MitoPlate S-1
• Unraveling Heterogeneity of Cellular Redox Responses During Metabolic Priming
• Metabolic Priming in NHDF Reveals Redox-Dependent Adaptations