Stephen Lai

Publications

• Reply to N. Hirshoren et al and D. Chakrabarti et al
• Cough strength and expiratory force in aspirating and nonaspirating postradiation head and neck cancer survivors
• Self-Reported Trismus: prevalence, severity and impact on quality of life in oropharyngeal cancer survivorship: a cross-sectional survey report from a comprehensive cancer center
• Head and neck surgical oncology in the time of a pandemic: Subsite-specific triage guidelines during the COVID-19 pandemic.
• Ultra‐small superparamagnetic iron oxide (USPIO) magnetic resonance imaging in benign mixed tumor of the parotid gland
• Erratum: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma (Oncotarget (2016) 7 (26307-26330) DOI: 10.18632/oncotarget.8368)
• Xerostomia
• Erratum to: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma (Nature Medicine, (2018), 24, 11, (1649-1654), 10.1038/s41591-018-0197-1)
• Effect of Tumor Size and Minimal Extrathyroidal Extension in Patients with Differentiated Thyroid Cancer
• Erratum: Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: Cross-sectional assessment of a prospective symptom survey in patients ≥65 years old. [Radiation Oncology 12, (2017) (150)] DOI: 10.1186/s13014-017-0878-9
• A prospective longitudinal assessment of MRI signal intensity kinetics of non-target muscles in patients with advanced stage oropharyngeal cancer in relationship to radiotherapy dose and post-treatment radiation-associated dysphagia: Preliminary findings from a randomized trial
• Investigation of radiomic signatures for local recurrence using primary tumor texture analysis in oropharyngeal head and neck cancer patients
• Data descriptor: Dynamic contrastenhanced magnetic resonance imaging for head and neck cancers
• Usefulness of surveillance imaging in patients with head and neck cancer who are treated with definitive radiotherapy
• Influence of parameter accuracy on pharmacokinetic analysis of hyperpolarized pyruvate
• Development and characterization of a rabbit model of compromised maxillofacial wound healing
• Conditional survival analysis of patients with locally advanced laryngeal cancer: Construction of a dynamic risk model and clinical nomogram
• Erratum to: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma (Nature Medicine, (2018), 24, 11, (1649-1654), 10.1038/s41591-018-0197-1)
• Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
• Radiotherapy dose–volume parameters predict videofluoroscopy-detected dysphagia per DIGEST after IMRT for oropharyngeal cancer: Results of a prospective registry
• Grading Dysphagia as a Toxicity of Head and Neck Cancer: Differences in Severity Classification Based on MBS DIGEST and Clinical CTCAE Grades
• Facilitating anaplastic thyroid cancer specialized treatment: A model for improving access to multidisciplinary care for patients with anaplastic thyroid cancer
• Dynamic Imaging Grade of Swallowing Toxicity (DIGEST): Scale development and validation
• Adjuvant external beam radiotherapy in locally advanced differentiated thyroid cancer
• Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation
• Imaging-Genomic Study of Head and Neck Squamous Cell Carcinoma: Associations Between Radiomic Phenotypes and Genomic Mechanisms via Integration of The Cancer Genome Atlas and The Cancer Imaging Archive
• Delayed lower cranial neuropathy after oropharyngeal intensity-modulated radiotherapy: A cohort analysis and literature review
• Expiratory muscle strength training for radiation-associated aspiration after head and neck cancer: A case series
• Age-adjusted comorbidity and survival in locally advanced laryngeal cancer
• Association of lymph node density with survival of patients with papillary thyroid cancer
• Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation
• Cognitive function and patient-reported memory problems after radiotherapy for cancers at the skull base: A cross-sectional survivorship study using the Telephone Interview for Cognitive Status and the MD Anderson Symptom Inventory-Head and Neck Module
• Publisher Correction: A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations (Scientific Reports (2017) DOI: 10.1038/s41598-017-11554-w)
• Machine learning applications in head and neck radiation oncology: Lessons from open-source radiomics challenges
• Management of the lateral neck compartment in patients with sporadic medullary thyroid cancer
• Self-reported oral morbidities in long-term oropharyngeal cancer survivors: A cross-sectional survey of 906 survivors
• Single-item discrimination of quality-of-life–altering dysphagia among 714 long-term oropharyngeal cancer survivors: Comparison of patient-reported outcome measures of swallowing
• A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations
• Predicting treatment Response based on Dual assessment of magnetic resonance Imaging kinetics and Circulating Tumor cells in patients with Head and Neck cancer (PREDICT-HN): Matching 'liquid biopsy' and quantitative tumor modeling
• Incompletely treated malignancies of the major salivary gland: Toward evidence-based care
• Symptom burden associated with late lower cranial neuropathy in long-term oropharyngeal cancer survivors
• Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism
• Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies
• Three-dimensional imaging assessment of anatomic invasion and volumetric considerations for chemo/radiotherapy-based laryngeal preservation in T3 larynx cancer
• Incidental detection of oropharyngeal cancer with fluciclovine PET
• Dose-volume correlates of mandibular osteoradionecrosis in Oropharynx cancer patients receiving intensity-modulated radiotherapy: Results from a case-matched comparison
• The impact of induction and/or concurrent chemoradiotherapy on acute and late patient‐reported symptoms in oropharyngeal cancer: Application of a mixed‐model analysis of a prospective observational cohort registry
• Role of sentinel lymph node biopsy for oral squamous cell carcinoma: Current evidence and future challenges
• Development and application of an elastic net logistic regression model to investigate the impact of cardiac substructure dose on radiation-induced pericardial effusion in patients with NSCLC
• Normal Tissue Complication Probability (NTCP) prediction model for osteoradionecrosis of the mandible in head and neck cancer patients following radiotherapy: Large-scale observational cohort
• Radiation therapy dose is associated with improved survival for unresected anaplastic thyroid carcinoma: Outcomes from the National Cancer Data Base
• Long-term outcomes after multidisciplinary management of T3 laryngeal squamous cell carcinomas: Improved functional outcomes and survival with modern therapeutic approaches
• Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer
• Magnetic resonance imaging of swallowing-related structures in nasopharyngeal carcinoma patients receiving IMRT: Longitudinal dose-response characterization of quantitative signal kinetics
• Beyond mean pharyngeal constrictor dose for beam path toxicity in non-target swallowing muscles: Dose-volume correlates of chronic radiation-associated dysphagia (RAD) after oropharyngeal intensity modulated radiotherapy
• Metabolic imaging as a biomarker of early radiation response in tumors
• Kinetic modeling and constrained reconstruction of hyperpolarized [1-13C]-pyruvate offers improved metabolic imaging of tumors
• Prognostic value of pretherapy platelet elevation in oropharyngeal cancer patients treated with chemoradiation
• Real-Time Genomic Characterization Utilizing Circulating Cell-Free DNA in Patients with Anaplastic Thyroid Carcinoma
• Thyroid Gland Malignancies
• Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2
• Association of TERT promoter mutation, but not BRAF mutation, with increased mortality in PTC
• Prospective observer and software-based assessment of magnetic resonance imaging quality in head and neck cancer: Should standard positioning and immobilization be required for radiation therapy applications?
• Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: Cross-sectional assessment of a prospective symptom survey in patients ≥65 years old
• Quantitative pretreatment CT volumetry: Association with oncologic outcomes in patients with T4a squamous carcinoma of the larynx
• Feeding Tube Utilization in Patients with Salivary Gland Malignancies
• Patterns-of-failure guided biological target volume definition for head and neck cancer patients: FDG-PET and dosimetric analysis of dose escalation candidate subregions
• Single agent nanoparticle for radiotherapy and radio-photothermal therapy in anaplastic thyroid cancer
• Consensus on the existence of functional erythropoietin receptors on cancer cells
• Correction to Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 [Molecular Cell 61, 520-534, (2016)]
• Predicting two-year longitudinal MD Anderson Dysphagia Inventory outcomes after intensity modulated radiotherapy for locoregionally advanced oropharyngeal carcinoma
• Magnetic Resonance Imaging of Glucose Uptake and Metabolism in Patients with Head and Neck Cancer
• High-throughput hyperpolarized 13C metabolic investigations using a multi-channel acquisition system
• Outcomes of oral cavity cancer patients treated with surgery followed by postoperative intensity modulated radiation therapy
• Feasibility of multianimal hyperpolarized 13C MRS
• Dynamic contrast-enhanced MRI detects acute radiotherapy-induced alterations in mandibular microvasculature: Prospective assessment of imaging biomarkers of normal tissue injury
• A novel perfused Bloch-McConnell simulator for analyzing the accuracy of dynamic hyperpolarized MRS
• Improving patient outcomes through multidisciplinary treatment planning conference
• Sialendoscopy for Patients with Radioiodine-Induced Sialadenitis and Xerostomia
• Lymphedema outcomes in patients with head and neck cancer
• Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: Quantitative spatial and dosimetric analysis using a deformable image registration workflow
• Osteoradionecrosis in patients with salivary gland malignancies
• [99mTc]Tilmanocept Accurately Detects Sentinel Lymph Nodes and Predicts Node Pathology Status in Patients with Oral Squamous Cell Carcinoma of the Head and Neck: Results of a Phase III Multi-institutional Trial
• Long-Term, Prospective Performance of the MD Anderson Dysphagia Inventory in “Low-Intermediate Risk” Oropharyngeal Carcinoma After Intensity Modulated Radiation Therapy
• The role of elective nodal irradiation for esthesioneuroblastoma patients with clinically negative neck
• Patterns of Treatment Failure in Anaplastic Thyroid Carcinoma
• An audit and feedback system for effective quality improvement in head and neck surgery: Can we become better surgeons?
• Intravoxel incoherent motion imaging kinetics during chemoradiotherapy for human papillomavirus-associated squamous cell carcinoma of the oropharynx: Preliminary results from a prospective pilot study
• Regulation of receptor tyrosine kinases by miRNA: Overexpression of miRNA using lentiviral inducible expression vectors
• Reduced feeding tube duration with intensity-modulated radiation therapy for head and neck cancer: A Surveillance, Epidemiology, and End Results-Medicare Analysis
• Intensity-modulated proton therapy and osteoradionecrosis in oropharyngeal cancer
• Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience
• Development and feasibility of a specialty-specific national surgical quality improvement program (NSQIP): The head and neck-reconstructive surgery NSQIP
• Development and characterization of six new human papillary thyroid carcinoma cell lines
• Symptom burden and dysphagia associated with osteoradionecrosis in long-term oropharynx cancer survivors: A cohort analysis
• Treatment and survival of patients with insular thyroid carcinoma: 508 cases from the National Cancer Data Base
• Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
• Matched computed tomography segmentation and demographic data for oropharyngeal cancer radiomics challenges
• Metabolic interrogation as a tool to optimize chemotherapeutic regimens
• Acute tumor lactate perturbations as a biomarker of genotoxic stress: Development of a biochemical model
• A shifting paradigm for patients with head and neck cancer: Transoral Robotic Surgery (TORS)
• Etodolac improves 5-FU sensitivity of head and neck cancer cells through inhibition of thymidylate synthase
• Gastrostomy tube placement in patients with oropharyngeal carcinoma treated with radiotherapy or chemoradiotherapy: Factors affecting placement and dependence
• Basal cell adenocarcinoma of a hard palate minor salivary gland: case report and review of the literature.
• Reassessments of ESAs for cancer treatment in the US and Europe
• Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy
• Radial spectroscopic MRI of hyperpolarized [1-13C] pyruvate at 7 tesla
• Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer
• Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
• Detection of thyroid cancer stem cells in papillary thyroid carcinoma
• Superimposed infection in mandibular osteoradionecrosis: Diagnosis and outcomes
• Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer
• Sorafenib in metastatic thyroid cancer: A systematic review
• Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma
• Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
• Association between pharmaceutical support and basic science research on erythropoiesis-stimulating agents
• Mucoepidermoid carcinoma of upper aerodigestive tract: Clinicopathologic study of 78 cases with immunohistochemical analysis of dicer expression
• Src inhibitors in suppression of papillary thyroid carcinoma growth
• Fast, reproducible measurement of the vascular input function in mice using constrained reconstruction and cardiac sampling
• Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy
• Evaluation of hyperpolarized [1-13C]-pyruvate by magnetic resonance to detect ionizing radiation effects in real time
• Coordinated targeting of the EGFR signaling axis by MicroRNA-27a*
• HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance
• Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
• MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo
• Functional relevance of miRNA* sequences in human disease
• Stereotactic Body Radiotherapy for Recurrent Squamous Cell Carcinoma of the Head and Neck: Results of a Phase I Dose-Escalation Trial
• In reply
• Mutational landscape of aggressive cutaneous squamous cell carcinoma
• Eat and exercise during radiotherapy or chemoradiotherapy for pharyngeal cancers: Use it or lose it
• Quality and performance indicators in an Academic Department of Head and Neck Surgery
• Multidisciplinary management of lacrimal sac/nasolacrimal duct carcinomas
• Minimally invasive video-assisted thyroidectomy: Expanded indications and oncologic completeness
• Gastrostomy tube placement in patients with hypopharyngeal cancer treated with radiotherapy or chemoradiotherapy: Factors affecting placement and dependence
• Head and neck Cancer an evolving treatment paradigm
• Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
• A throughput-optimized array system for multiple-mouse MRI
• Response assessment by combined PET-CT scan versus ct scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy
• Re: Sorafenib in thyroid cancer patients: Learning from toxicity
• Phosphaturic mesenchymal tumor: A report of 6 patients treated at a single institution and comparison with reported series
• Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model
• Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation
• STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma
• Chemoradiotherapy for maxillary sinus adenoid cystic carcinoma using superselective intra-arterial infusion via a superficial temporal artery
• Management of squamous cell carcinoma of the base of tongue with chemoradiation and brachytherapy
• A review of safety, efficacy, and utilization of erythropoietin, darbepoetin, and peginesatide for patients with cancer or chronic kidney disease: A report from the southern network on adverse reactions (SONAR)
• Correction: Tumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and Histologic characteristics of human cancers
• Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
• Sentinel lymph node biopsy for oral cancer: Supporting evidence and recent novel developments
• Pathology quiz case 2
• Oligomerization and scaffolding functions of the erythropoietin receptor cytoplasmic tail
• Thyroid Cancer
• Dysregulation of Hypoxia Inducible Factor-1α Head and Neck Squamous Cell Carcinoma Cell Lines Correlates with Invasive Potential
• The roles of JAK kinases in 1nterleukin-4 and interleukin-7-mediated signaling
• Molecular analysts of the il-4rct and yc subunits reveals a novel mechanism for 1nterleukin-4 receptor-mediated signaling
• Interleukin-2 receptor signaling specificity derives from redundant and multifunctional tyrosine residues of the il-2rβ Chain
• Distinct tyrosine residues within the interleukin-2 receptor β chain drive signal transduction specificity, redundancy and diversity
• Retropharyngeal aberrant thymus.
• Vocal fold granuloma: The 'ball-valve' phenomenon
• Genetic evidence for an additional factor required for erythropoietin- induced signal transduction
• Redundant and selective roles for erythropoietin receptor tyrosines in erythropoiesis in vivo
• Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor α subunit
• Tracheostomy: Demystifying an ancient technique
• Supracricoid partial laryngectomy with cricohyoidepiglottopexy
• Sphenoid encephaloceles: Disease management and identification of lesions within the lateral recess of the sphenoid sinus
• Identification of a variable region within the cytoplasmic tail of the IL- 2 receptor β chain that is required for growth signal transduction
• Bilateral squamous cell carcinoma of the external auditory canals
• Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the β chain and non-tyrosine residues of the γ(c) chain
• Parotidectomy in the treatment of aggressive cutaneous malignancies
• Distinct tyrosine residues within the interleukin-2 receptor β chain drive signal transduction specificity, redundancy, and diversity
• Head and neck squamous cell carcinoma cell lines: Established models and rationale for selection
• Heteromerization of the γ(c) chain with the interleukin-9 receptor subunit leads to STAT activation and prevention of apoptosis
• Shared γ(c) subunit within the human interleukin-7 receptor complex: A molecular basis for the pathogenesis of x-linked severe combined immunodeficiency
• Cutaneous malignancies of the head and neck
• Identification of upper respiratory bacterial pathogens with the electronic nose
• The molecular role of the common γ subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes
• Erratum: Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma (Oncogene (2005) 24 (4442-4449) DOI:10.1038/sj.onc.1208635)
• Radiology quiz case 2
• Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: The utility of PET-CT
• Allergic rhinitis in children
• Reconstruction of the lateral mandibulectomy defect: Management based on prognosis and location and volume of soft tissue resection
• Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
• Signaling through the interleukin 2 receptor β chain activates a STAT-5- like DNA-binding activity
• Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma
• Clinical care pathway for head and neck cancer: A valuable tool for decreasing resource utilization
• Research education and training in otolaryngology: Meeting summary and research opportunities
• Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma
• Reconstruction of the marginal mandibulectomy defect: an update
• High-risk non-melanoma skin cancer of the head and neck
• Reconstruction of the through-and-through anterior mandibulectomy defect: Indications and limitations of the double-skin paddle fibular free flap
• Understanding the presence and function of erythropoietin receptors on cancer cells
• Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma
• The association between thyroid differentiation score and survival outcomes in papillary thyroid carcinoma
• The Association Between Thyroid Differentiation Score and Survival Outcomes in Papillary Thyroid Carcinoma
• Cost-Effectiveness of Personalized Policies for Implementing Organ-at-Risk Sparing Adaptive Radiation Therapy in Head and Neck Cancer: A Markov Decision Process Approach
• In Vivo Test-retest Quantitative Characterization of Echo Planar Imaging Apparent Diffusion Coefficient Reproducibility for Head and Neck Cancers on a 1.5T MR-Linac Platform: Technical Validation using QIBA Metrology