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Sarah Hooper

0000-0003-2452-3757

Reader in Microbiology & Infection (Biological sciences; Biomedical and clinical sciences; Health sciences)

Cardiff

The aim of my research is to unravel the complex interactions between pathogens and their host during the infection process. The crux of these studies lies in understanding how pathogens hijack host processes and exploiting novel ways of impairing inter-bacterial and host-pathogen interactions to diagnose and facilitate the clearance of infection. These principles enable a targeted approach to infectious disease control in an era where the conservation of traditional antimicrobial treatments is paramount. This central focus of my research includes complex biofilm and co-culture models that closely mimic the host environment to better understand chronic wound infection and test clinically relevant hypotheses.

Publications

  • TA-AgNPs/Alginate Hydrogel and Its Potential Application as a Promising Antibiofilm Material against Polymicrobial Wound Biofilms Using a Unique Biofilm Flow Model
  • Bacteriology methods for the study of infectious diseases
  • Microbial communities within the chronic wound
  • Novel targets of antimicrobial therapies
  • Dual stimulation with bacterial and viral components increases the expression of hepcidin in human monocytes
  • Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins
  • The effect of the flavonol morin on adhesion and aggregation of Streptococcus pyogenes
  • Functionalization of ethylene vinyl acetate with antimicrobial chlorhexidine hexametaphosphate nanoparticles
  • The AgI/II Family Adhesin AspA Is Required for Respiratory Infection by Streptococcus pyogenes
  • A novel antibacterial peptide derived from Crocodylus siamensis haemoglobin hydrolysate induces membrane permeabilization causing iron dysregulation, oxidative stress and bacterial death
  • Erratum: Manuka honey inhibits adhesion and invasion of medically important wound bacteria in vitro. (Future Microbiology 8(12), 1523-1536 (2013))
  • The antibacterial activity of date syrup polyphenols against S. aureus and E. coli
  • Interaction between Staphylococcus aureus and Pseudomonas aeruginosa is beneficial for colonisation and pathogenicity in a mixed biofilm
  • Streptococcus pyogenes antigen I/II-family polypeptide AspA shows differential ligand-binding properties and mediates biofilm formation
  • Micro-management: curbing chronic wound infection
  • Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes
  • Feo - Transport of ferrous iron into bacteria
  • Draft genome sequence of Pseudomonas aeruginosa ATCC 9027, originally isolated from an outer ear infection
  • A requirement for flow to enable the development of Ureaplasma parvum biofilms in vitro
  • Molecular exploration for Mycoplasma amphoriforme, Mycoplasma fermentans and Ureaplasma spp. in patient samples previously investigated for Mycoplasma pneumoniae infection
  • Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.)
  • Manuka honey is bactericidal against Pseudomonas aeruginosa and results in differential expression of oprF and algD
  • Exposure of Escherichia coli to human hepcidin results in differential expression of genes associated with iron homeostasis and oxidative stress
  • Honey: A sweet solution to the growing problem of antimicrobial resistance?
  • Manuka honey inhibits adhesion and invasion of medically important wound bacteria in vitro
  • Manuka honey inhibits the development of Streptococcus pyogenes biofilms and causes reduced expression of two fibronectin binding proteins
  • The changing faces of Streptococcus antigen I/II polypeptide family adhesins: MicroReview
  • Date syrup-derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase-2 expression in endothelial cells
  • Novel targets of antimicrobial therapies
  • Volatile Organic Compounds in the Early Diagnosis of Non-healing Surgical Wounds: A Systematic Review
  • Chlorhexidine hexametaphosphate as a wound care material coating: Antimicrobial efficacy, toxicity and effect on healing
  • A novel flow-system to establish experimental biofilms for modelling chronic wound infection and testing the efficacy of wound dressings
  • Manuka honey inhibits siderophore production in Pseudomonas aeruginosa
  • Editorial: Polymicrobial Biofilms in Chronic Infectious Disease
  • Manuka honey treatment of biofilms of Pseudomonas aeruginosa results in the emergence of isolates with increased honey resistance
  • Synthesis, characterization, and efficacy of antimicrobial chlorhexidine hexametaphosphate nanoparticles for applications in biomedical materials and consumer products
  • A Synthetic Polymicrobial Community Biofilm Model Demonstrates Spatial Partitioning, Tolerance to Antimicrobial Treatment, Reduced Metabolism, and Small Colony Variants Typical of Chronic Wound Biofilms
  • Alginate films augmented with chlorhexidine hexametaphosphate particles provide sustained antimicrobial properties for application in wound care
  • Testing the efficacy of topical antimicrobial treatments using a two‐ and five‐species chronic wound biofilm model
  • Long-Term Stability and Efficacy of NCT Solutions
  • In Vitro Cytotoxicity and Antimicrobial Activity against Acne-Causing Bacteria and Phytochemical Analysis of Galangal (Alpinia galanga) and Bitter Ginger (Zingiber zerumbet) Extracts

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