Sara Gosline

Publications

• Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data with ImmClassifier
• Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
• Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens
• A high-throughput molecular data resource for cutaneous neurofibromas
• Systems approaches to cancer biology
• Cutaneous neurofibromas in the genomics era: current understanding and open questions
• The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes
• Refining protein subcellular localization.
• SAMNet: A network-based approach to integrate multi-dimensional high throughput datasets
• Antibody colocalization microarray: a scalable technology for multiplex protein analysis in complex samples.
• Posttranscriptional regulation of per1 underlies the oncogenic function of IREα
• Linking Proteomic and Transcriptional Data through the Interactome and Epigenome Reveals a Map of Oncogene-induced Signaling
• SAMNetWeb: Identifying condition-specific networks linking signaling and transcription
• Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements
• Supplemental Figures and Table from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Data from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Supplemental Figures and Table from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Data from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Proteome mapping of the human pancreatic islet microenvironment reveals endocrine-exocrine signaling sphere of influence
• The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance.
• Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML.
• Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells
• Decomprolute: A benchmarking platform designed for multiomics-based tumor deconvolution
• Quantitative Proteomics Analysis of the Secretory Pathway
• Intracellular eukaryotic parasites have a distinct unfolded protein response
• Network-Based Interpretation of Diverse High-Throughput Datasets through the Omics Integrator Software Package
• BayesDeBulk: A Flexible Bayesian Algorithm for the Deconvolution of Bulk Tumor Data
• Probing the chemical-biological relationship space with the Drug Target Explorer
• Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1
• leapR: An R Package for Multiomic Pathway Analysis
• A field guide to cultivating computational biology
• A rapid platform for 3D patient-derived cutaneous neurofibroma organoid establishment and screening
• CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors
• Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology
• Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia
• Decomprolute is a benchmarking platform designed for multiomics-based tumor deconvolution
• Supplemental Figures and Table from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Supplemental Figures and Table from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Data from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Data from Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway
• Cutaneous neurofibromas in the genomics era: Current understanding and open questions
• The evolution and multi-molecular properties of NF1 cutaneous neurofibromas originating from C-fiber sensory endings and terminal Schwann cells at normal sites of sensory terminations in the skin
• Proteomics and Phosphoprotoemic Measurements Enhance Ability to Predict Ex Vivo Drug Response in AML
• Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1)
• Engaging a community to enable disease-centric data sharing with the NF Data Portal
• The AML Microenvironment Catalyzes a Step-Wise Evolution to Gilteritinib Resistance
• Mass Spectrometry–Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine
• Proteogenomic data and resources for pan-cancer analysis
• Utilizing proteomics and phosphoproteomics to predict ex vivo drug sensitivity across genetically diverse AML patients
• Chromosome 8 gain is associated with high-grade transformation in MPNST
• The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β–mediated AML progression
• Mapping the Proteogenomic Landscape Enables Prediction of Drug Response in Acute Myeloid Leukemia
• Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
• Pan-cancer proteogenomics connects oncogenic drivers to functional states
• A clinically and genomically annotated nerve sheath tumor biospecimen repository
• Chromosome 8 gain is associated with high-grade transformation in MPNST
• Knowledge-based classification of fine-grained immune cell types in single-cell RNA-Seq data
• CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors
• Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor heterogeneity in NF1
• Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
• A clinically and genomically annotated nerve sheath tumor biospecimen repository
• Probing the chemical–biological relationship space with the Drug Target Explorer
• Current and future directions in network biology
• Deep learning integrates histopathology and proteogenomics at a pan-cancer level
• Pan-cancer proteogenomics characterization of tumor immunity