Sandra Citi

Publications

• Epithelial junctions and Rho family GTPases: the zonular signalosome
• Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity
• PLEKHA7 modulates epithelial tight junction barrier function
• ZO proteins redundantly regulate the transcription factor DbpA/ZONAB
• Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo
• MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly
• The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas
• The adherens junctions control susceptibility to Staphylococcus aureus $α$-toxin
• Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions.
• Tight junction proteins.
• Cingulin and actin mediate midbody-dependent apical lumen formation during polarization of epithelial cells
• The tight junction protein cingulin regulates gene expression and RhoA signaling.
• Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.
• The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4.
• Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.
• Cingulin, paracingulin, and PLEKHA7: signaling and cytoskeletal adaptors at the apical junctional complex.
• Distinct domains of paracingulin are involved in its targeting to the actin cytoskeleton and regulation of apical junction assembly.
• Tight junction biogenesis in the early Xenopus embryo.
• The control of gene expression and cell proliferation by the epithelial apical junctional complex.
• A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
• Regulation of small GTPases at epithelial cell-cell junctions.
• PLEKHA7 is an adherens junction protein with a tissue distribution and subcellular localization distinct from ZO-1 and E-cadherin.
• The cytoplasmic plaque of tight junctions: a scaffolding and signalling center.
• Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
• Tight junction formation in early Xenopus laevis embryos: identification and ultrastructural characterization of junctional crests and junctional vesicles.
• Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
• Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
• Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition.
• Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
• Disruption of the cingulin gene does not prevent tight junction formation but alters gene expression.
• What's new in tight junctions: a report on the 2002 ASCB Meeting, San Francisco, CA.
• Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.
• Molecular complexity of vertebrate tight junctions (Review).
• Cingulin interacts with F-actin in vitro.
• Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction.
• Introduction: opening up tight junctions
• Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.
• Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin.
• Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin.
• Xenopus laevis occludin. Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin.
• Experimental colitis increases small intestine permeability in the rat.
• Occludin dephosphorylation in early development of Xenopus laevis.
• Hepatocyte tight-junctional permeability is increased in rat experimental colitis.
• Tight junctions in early amphibian development: detection of junctional cingulin from the 2-cell stage and its localization at the boundary of distinct membrane domains in dividing blastomeres in low calcium.
• Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice. Characterization of cell lines with distinct properties.
• Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells.
• Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites.
• Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7.
• Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system.
• PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins
• Immunological and biochemical studies on the structure and function of brush border myosin.
• The molecular organization of tight junctions.
• Tight junction protein cingulin is expressed by maternal and embryonic genomes during early mouse development.
• Localisation of tight junction protein cingulin is temporally and spatially regulated during early mouse development.
• Polarized functions and permeability properties of rat epididymal epithelial cells in vitro.
• Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
• The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells.
• Cingulin, a specific protein component of tight junctions, is expressed in normal and neoplastic human epithelial tissues.
• Localization of myosin in the cytoskeleton of brush border cells using monoclonal antibodies and confocal laser-beam scanning microscopy.
• ZO-1 and cingulin: tight junction proteins with distinct identities and localizations.
• Parallel modulation of brush border myosin conformation and enzyme activity induced by monoclonal antibodies.
• Cingulin: characterization and localization.
• Modulation of cellular morphology and locomotory activity by antibodies against myosin.
• Active site trapping of nucleotide by smooth and non-muscle myosins.
• How phosphorylation controls the self-assembly of vertebrate smooth and non-muscle myosins.
• Brush border myosin filament assembly and interaction with actin investigated with monoclonal antibodies.
• Cingulin, a new peripheral component of tight junctions.
• Polymerization of vertebrate non-muscle and smooth muscle myosins.
• Effects of light chain phosphorylation and skeletal myosin on the stability of non-muscle myosin filaments.
• Regulation of non-muscle myosin structure and function.
• Studies on the structure and conformation of brush border myosin using monoclonal antibodies.
• Regulation in vitro of brush border myosin by light chain phosphorylation.
• A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity
• LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β
• The mechanobiology of tight junctions
• Tension-Dependent Stretching Activates ZO-1 to Control the Junctional Localization of Its Interactors
• Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33
• PLEKHA5, PLEKHA6 and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis
• The PLEKHA7–PDZD11 complex regulates the localization of the calcium pump PMCA and calcium handling in cultured cells
• Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization
• Knock Out of CGN and CGNL1 in MDCK Cells Affects Claudin-2 but Has a Minor Impact on Tight Junction Barrier Function
• A short guide to the tight junction
• Cingulin–nonmuscle myosin interaction plays a role in epithelial morphogenesis and cingulin nanoscale organization
• Cingulin and paracingulin tether myosins-2 to junctions to mechanoregulate the plasma membrane
• Evidence for an interaction of paracingulin with microtubules
• A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics
• The knock-out of paracingulin attenuates hypertension through modulation of kidney ion transport