Sally Shirran

Publications

• Investigation of the blood proteome in response to spinal cord injury in rodent models
• Stathmin is enriched in the developing corticospinal tract.
• Structural analysis of leader peptide binding enables leader-free cyanobactin processing.
• Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development.
• Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus.
• Resource recovery from the anaerobic digestion of food waste is underpinned by cross-kingdom microbial activities
• On the interaction between human IQGAP1 and actin
• Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans.
• Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
• Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle
• Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure
• Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m1A22-tRNA methyltransferase TrmK
• The proteome signatures of fibroblasts from patients with severe, intermediate and mild spinal muscular atrophy show limited overlap
• Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS
• Carbapenem-only combination therapy against multi-drug resistant Pseudomonas aeruginosa
• Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles
• Synthesis of Next-Generation Maleimide Radical Labels
• Erratum to "Insights into the Biosynthesis of the Vibrio cholera Major Autoinducer CAI-1 from the Crystal Structure of the PLP-Dependent Enzyme CqsA" [J. Mol. Biol. (2009) 92, 763-773] (DOI:10.1016/j.jmb.2009.07.042)
• Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase.
• Rapid evolution and gene expression: a rapidly evolving Mendelian trait that silences field crickets has widespread effects on mRNA and protein expression.
• On the Interaction Between Human IQGAP1 and Actin.
• A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
• Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway.
• The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction.
• An enzymatic route to selenazolines.
• The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain.
• A comparison of the accuracy of iTRAQ quantification by nLC-ESI MSMS and nLC-MALDI MSMS methods.
• Insights into the biosynthesis of the Vibrio cholerae major autoinducer CAI-1 from the crystal structure of the PLP-dependent enzyme CqsA.
• The use of ESI-MS to probe the binding of divalent cations to calmodulin.
• The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS.
• hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases
• Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies
• An internal thioester in a pathogen surface protein mediates covalent host binding
• Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis
• The formation of a complex between calmodulin and neuronal nitric oxide synthase is determined by ESI-MS
• The major histocompatibility complex class I immunopeptidome of extracellular vesicles
• Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology
• Linking microbial community structure and function during the acidified anaerobic digestion of grass
• Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration
• Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation
• A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds
• Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells
• Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy"
• Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy
• Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging
• Substrate plasticity of a fungal peptide α-N-methyltransferase
• Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
• An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs
• Engineering of a peptide α-N-methyltransferase to methylate non-proteinogenic amino acids
• Direct synthesis of polyureas from the dehydrogenative coupling of diamines and methanol
• Assessing the impact of interfering organic matter on soil metaproteomic workflow
• Antiviral type III CRISPR signalling via conjugation of ATP and SAM
• AAV9-mediated SMN gene therapy rescues cardiac desmin but not Lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice
• A Discussion of Core Facility Biomarker Discovery
• Characterising the HLA-I Immunopeptidome of plasma-derived extracellular vesicles in patients with melanoma
• Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection
• Androgen receptor interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer.
• Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery