Richard Gomer

Publications

• F1000Prime Recommendation
• Functional similarities between the Dictyostelium protein AprA and the human protein Dipeptidyl-Peptidase IV.
• A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases.
• Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
• Secondary ion mass spectrometry imaging of Dictyostelium discoideum aggregation streams.
• Extracellular Polyphosphate Inhibits Proliferation in an Autocrine Negative Feedback Loop in Dictyostelium discoideum.
• Peritoneal Dialysis Fluid and Some of Its Components Potentiate Fibrocyte Differentiation.
• Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.
• TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation.
• Role of the neutrophil chemorepellent soluble dipeptidyl peptidase IV in decreasing inflammation in a murine model of arthritis.
• Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation.
• DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
• The long pentraxin PTX3 promotes fibrocyte differentiation.
• Regulating the Innate Immune System to Decrease LungInjury.
• Partial genetic suppression of a loss-of-function mutant of the neuronal ceroid lipofuscinosis-associated protease TPP1 in Dictyostelium discoideum.
• Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis.
• A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid p.
• Distinct Fcγ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.
• Serum amyloid P: a systemic regulator of the innate immune response.
• The p21-activated kinase (PAK) family member PakD is required for chemorepulsion and proliferation inhibition by autocrine signals in Dictyostelium discoideum.
• Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI.
• Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.
• A retinoblastoma orthologue is required for the sensing of a chalone in Dictyostelium discoideum.
• New approaches to modulating idiopathic pulmonary fibrosis.
• Trypsin potentiates human fibrocyte differentiation.
• Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent.
• A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsion.
• Serum amyloid P inhibits granulocyte adhesion.
• NaCl potentiates human fibrocyte differentiation.
• A secreted protein is an endogenous chemorepellant in Dictyostelium discoideum.
• FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.
• Differentiation of circulating monocytes into fibroblast-like cells.
• Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology.
• Alternative origins of stroma in normal organs and disease.
• High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation.
• The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium.
• Cell density sensing and size determination.
• Pirfenidone treatment of idiopathic pulmonary fibrosis.
• Initial cell type choice in Dictyostelium.
• Toll-like receptor 2 agonists inhibit human fibrocyte differentiation.
• Improved serum-free culture conditions for spleen-derived murine fibrocytes.
• The ROCO kinase QkgA is necessary for proliferation inhibition by autocrine signals in Dictyostelium discoideum.
• The secreted proteome profile of developing Dictyostelium discoideum cells.
• Investigational approaches to therapies for idiopathic pulmonary fibrosis.
• Gadolinium-containing magnetic resonance image contrast agent promotes fibrocyte differentiation.
• Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.
• Improved serum-free culture conditions for the differentiation of human and murine fibrocytes.
• A Dictyostelium chalone uses G proteins to regulate proliferation.
• A cell number counting factor alters cell metabolism.
• Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation.
• A cell number-counting factor regulates the cytoskeleton and cell motility in Dictyostelium.
• A serum amyloid P-binding hydrogel speeds healing of partial thickness wounds in pigs.
• A protein with similarity to PTEN regulates aggregation territory size by decreasing cyclic AMP pulse size during Dictyostelium discoideum development.
• Combining experiments and modelling to understand size regulation in Dictyostelium discoideum.
• The secreted Dictyostelium protein CfaD is a chalone.
• Circulating progenitor cells and scleroderma.
• Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation.
• Serum amyloid P inhibits dermal wound healing.
• CnrN regulates Dictyostelium group size using a counting factor-independent mechanism.
• Serum amyloid P and fibrosis in systemic sclerosis: comment on the article by Tennent et al.
• Reduction of bleomycin-induced pulmonary fibrosis by serum amyloid P.
• A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium.
• A G protein-coupled receptor with a lipid kinase domain is involved in cell-density sensing.
• Complexity of the Neurospora crassa circadian clock system: multiple loops and oscillators.
• Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice.
• A putative Ariadne-like ubiquitin ligase is required for Dictyostelium discoideum development.
• A 60-kilodalton protein component of the counting factor complex regulates group size in Dictyostelium discoideum.
• Two circadian timing circuits in Neurospora crassa cells share components and regulate distinct rhythmic processes.
• A protein in crude cytosol regulates glucose-6-phosphatase activity in crude microsomes to regulate group size in Dictyostelium.
• Aggregated IgG inhibits the differentiation of human fibrocytes.
• Mathematically modelling the effects of counting factor in Dictyostelium discoideum.
• A secreted factor represses cell proliferation in Dictyostelium.
• A cysteine-rich extracellular protein containing a PA14 domain mediates quorum sensing in Dictyostelium discoideum.
• Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum.
• A single cell density-sensing factor stimulates distinct signal transduction pathways through two different receptors.
• A cell number counting factor regulates Akt/protein kinase B to regulate Dictyostelium discoideum group size.
• [How to reach the right size?].
• Multiple oscillators regulate circadian gene expression in Neurospora.
• Inhibition of fibrocyte differentiation by serum amyloid P.
• A second UDP-glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum.
• Two components of a secreted cell number-counting factor bind to cells and have opposing effects on cAMP signal transduction in Dictyostelium.
• Disruption of aldehyde reductase increases group size in dictyostelium.
• CF45-1, a secreted protein which participates in Dictyostelium group size regulation.
• Disrupted function of tumor necrosis factor-alpha-stimulated gene 6 blocks cumulus cell-oocyte complex expansion.
• The versatile Dictyostelium discoideum. Meeting report: International Dictyostelium Conference 2002.
• A secreted cell number counting factor represses intracellular glucose levels to regulate group size in dictyostelium.
• Overexpression of White Collar-1 (WC-1) activates circadian clock-associated genes, but is not sufficient to induce most light-regulated gene expression in Neurospora crassa.
• The different components of a multisubunit cell number-counting factor have both unique and overlapping functions.
• The cdk5 homologue, crp, regulates endocytosis and secretion in dictyostelium and is necessary for optimum growth and differentiation.
• Cells respond to and bind countin, a component of a multisubunit cell number counting factor.
• Cell motility mediates tissue size regulation in Dictyostelium.
• ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium.
• A cell number-counting factor regulates group size in Dictyostelium by differentially modulating cAMP-induced cAMP and cGMP pulse sizes.
• Cell cycle phase, cellular Ca2+ and development in Dictyostelium discoideum.
• Not being the wrong size.
• A precise group size in Dictyostelium is generated by a cell-counting factor modulating cell-cell adhesion.
• A protein containing a serine-rich domain with vesicle fusing properties mediates cell cycle-dependent cytosolic pH regulation.
• A putative receptor mediating cell-density sensing in Dictyostelium.
• A cell-counting factor regulating structure size in Dictyostelium.
• Gene identification by shotgun antisense.
• A strategy to study development and pattern formation: use of antibodies against products of cloned genes.
• A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium.
• Cell density sensing mediated by a G protein-coupled receptor activating phospholipase C.
• Antisense: a key tool for cell and developmental studies in Dictyostelium.
• Cell-density sensing: come on inside and tell us about it.
• A cell-density sensing factor regulates the lifetime of a chemoattractant-induced G alpha-GTP conformation.
• RtoA links initial cell type choice to the cell cycle in Dictyostelium.
• The cell density factor CMF regulates the chemoattractant receptor cAR1 in Dictyostelium.
• A Dictystelium mutant with defective aggregate size determination.
• Mutagenesis and gene identification in Dictyostelium by shotgun antisense.
• A cell-cycle phase-associated cell-type choice mechanism monitors the cell cycle rather than using an independent timer.
• PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium.
• Initial cell-type choice in a simple eukaryote: cell-autonomous or morphogen-gradient dependent?
• A density-sensing factor regulates signal transduction in Dictyostelium.
• Intercellular signalling. Knowing that you're among friends.
• Cell density-sensing in Dictyostelium by means of the accumulation rate, diffusion coefficient and activity threshold of a protein secreted by starved cells.
• A developmentally regulated cell surface receptor for a density-sensing factor in Dictyostelium.
• Different temporal patterns of expression result in the same type, amount, and distribution of filamin (ABP) in cardiac and skeletal myofibrils.
• Skelemin, a cytoskeletal M-disc periphery protein, contains motifs of adhesion/recognition and intermediate filament proteins.
• Characterization of the signal transduction pathways and cis-acting DNA sequence responsible for the transcriptional induction during growth and development of the lysosomal alpha-mannosidase gene in Dictyostelium discoideum.
• Growing and starving Dictyostelium cells produce distinct density-sensing factors.
• A density-sensing factor controls development in Dictyostelium.
• Increasing specificity from the PCR-RACE technique.
• Regulation and processing of a secreted protein that mediates sensing of cell density in Dictyostelium.
• A secreted 80 x 10(3) Mr protein mediates sensing of cell density and the onset of development in Dictyostelium.
• Paralog chromatography.
• Mitoskelin: a mitochondrial protein found in cytoskeletal preparations.
• Cell-autonomous determination of cell-type choice in Dictyostelium development by cell-cycle phase.
• Cellular and subcellular distribution of a cAMP-regulated prestalk protein and prespore protein in Dictyostelium discoideum: a study on the ontogeny of prestalk and prespore cells.
• cAMP induction of prespore and prestalk gene expression in Dictyostelium is mediated by the cell-surface cAMP receptor.
• Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants.
• Spatial and temporal regulation of a foreign gene by a prestalk-specific promoter in transformed Dictyostelium discoideum.
• Regulation of the Dictyostelium ras gene during development and in transformants.
• Phenocopy of discoidin I-minus mutants by antisense transformation in Dictyostelium.
• Regulation of cell-type-specific gene expression in Dictyostelium.
• Developmental regulation of a Dictyostelium gene encoding a protein homologous to mammalian ras protein.
• Highly homologous filamin polypeptides have different distributions in avian slow and fast muscle fibers.
• Switching of filamin polypeptides during myogenesis in vitro.
• Heat shock proteins are methylated in avian and mammalian cells.
• The synthesis and deployment of filamin in chicken skeletal muscle.
• The role of filamin in the morphogenesis of the skeletal muscle sarcomere.