Richard Francis

Publications

• Mouse model of heterotaxy with single ventricle spectrum of cardiac anomalies
• Exploring the Genetic Basis for Congenital Heart Disease with Mouse Enu Mutagenesis
• Quantifying cilia beat frequency using high‐speed video microscopy: Assessing frame rate requirements when imaging different ciliated tissues
• Assessment of ciliary phenotype in primary ciliary dyskinesia by micro-optical coherence tomography
• Distribution of raphespinal fibers in the mouse spinal cord
• CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
• DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia
• ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning
• Automated identification of abnormal respiratory ciliary motion in nasal biopsies
• Global genetic analysis in mice unveils central role for cilia in congenital heart disease
• Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies
• Airway ciliary dysfunction and sinopulmonary symptoms in patients with congenital heart disease
• Decellularized Tracheal Extracellular Matrix Supports Epithelial Migration, Differentiation, and Function
• Dexmedetomidine and fentanyl exhibit temperature dependent effects on human respiratory cilia
• Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families
• IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment
• Increased postoperative respiratory complications in heterotaxy congenital heart disease patients with respiratory ciliary dysfunction
• Ion Torrent sequencing for conducting genome-wide scans for mutation mapping analysis
• The effects of temperature and anesthetic agents on ciliary function in murine respiratory epithelia
• Interrogating Congenital Heart Defects With Noninvasive Fetal Echocardiography in a Mouse Forward Genetic Screen
• ARMC4 Mutations Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry
• DYX1C1 is required for axonemal dynein assembly and ciliary motility
• Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
• Imaging techniques for visualizing and phenotyping congenital heart defects in murine models
• Microcomputed Tomography Provides High Accuracy Congenital Heart Disease Diagnosis in Neonatal and Fetal Mice
• Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton
• Connexin43 Modulates Cell Polarity and Directional Cell Migration by Regulating Microtubule Dynamics
• Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
• Congenital heart disease and the specification of left-right asymmetry
• High Prevalence of Respiratory Ciliary Dysfunction in Congenital Heart Disease Patients With Heterotaxy
• Ventricular Rotation Is Independent of Cardiac Looping: A Study in Mice With Situs Inversus Totalis Using Speckle-Tracking Echocardiography
• Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development
• Initiation and maturation of cilia-generated flow in newborn and postnatal mouse airway
• Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy
• Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity
• Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport
• Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation
• Mouse model of heterotaxy with single ventricle spectrum of cardiac anomalies
• Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia
• Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells
• Changes in activin and activin receptor subunit expression in rat liver during the development of CCl4-induced cirrhosis
• Connexin43 associated with an N-cadherin-containing multiprotein complex is required for gap junction formation in NIH3T3 cells
• Endothelin receptor A blockade ameliorates hypothermic ischemia-reperfusion-related microhemodynamic disturbances during liver transplantation in the rat
• 3D imaging of PSD-95 in the mouse brain using the advanced CUBIC method
• Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia
• Ultra-high frequency ultrasound biomicroscopy and high throughput cardiovascular phenotyping in a large scale mouse mutagenesis screen
• Novel use of differential image velocity invariants to categorize ciliary motion defects
• Erratum: Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice (Circulation: Cardiovascular Imaging (2013) 6 (551-559))
• The effects of acute hydrogen peroxide exposure on respiratory cilia motility and viability
• Autonomous and non-cell autonomous etiology of ciliopathy associated structural birth defects
• Autonomous and non-cell autonomous role of cilia in structural birth defects in mice
• Exploring the Genetic Basis for Congenital Heart Disease with Mouse ENU Mutagenesis
• Quantifying cilia beat frequency using high-speed video microscopy: Assessing frame rate requirements when imaging different ciliated tissues