I graduated from Nottingham University Medical School in 1994, completed clinical training in paediatric nephrology and began research training in 2004 with a Wellcome Research Training Fellowship to work in Peter Mathieson and Moin Saleem’s laboratory. I began an NIHR Clinical Lectureship in 2007 and in 2008 started working with Martin Humphries at the Wellcome Centre for Cell-Matrix Research in Manchester. In 2010 I was awarded a Wellcome Intermediate Clinical Fellowship to establish my research group and in 2016 a Wellcome Senior Research Fellowship. The research in my group is focused on understanding mechanisms of glomerular disease. The glomerular capillary wall is a sophisticated filtration barrier comprising endothelial cells, the glomerular basement membrane and specialised epithelial cells called podocytes. Basement membrane regulation is required for glomerular integrity and we seek to understand mechanisms of assembly, regulation and repair.