RAJAGOPAL AYANA

Publications

• Age-related dysregulation of the retinal transcriptome in African turquoise killifish
• Spatial mapping of the progenitor diversity in the aging model Nothobranchius furzeri
• Turning tides – Improving neurorepair in the aged killifish brain by rejuvenation
• Investigating the maturation and integration of newborn neurons using a viral vector strategy in the telencephalon of the African turquoise killifish (N. furzeri)
• Design and synthesis of imidazolidinone derivatives as potent anti-leishmanial agents by bioisosterism.
• Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani.
• Deconvolution of Human Brain Cell Type Transcriptomes Unraveled Microglia-Specific Potential Biomarkers.
• Plasmodium palmitoylation machinery engineered in E. coli for high-throughput screening of palmitoyl acyl-transferase inhibitors.
• Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani.
• Decoding Crucial LncRNAs Implicated in Neurogenesis and Neurological Disorders.
• Novel beta-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity.
• Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model
• Integrative omics in N. furzeri (killifish): Cells to systems biology of ageing
• Fishing for healthy aging secrets in the brain using a short lived killifish model
• Characterization of progenitor diversity in the aging brain with the use of a killifish transgenic toolbox
• The creation of a transgenic killifish toolbox to study adult neurogenesis
• A deep dive in the aged killifish brain: ameliorating functionality of newborn neurons
• Improving neurorepair in the aged brain, what the killifish pallium can tell
• Senolytic improvement of neurorepair in the aged N. furzeri brain
• Ameliorating functional integration of newborn neurons in the aged killifish telencephalon
• Rejuvenation improves neuroregeneration in the aged brain
• Unraveling the cell diversity of the short lived African turquoise killifish telencephalon
• A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish
• A small bioactive glycoside inhibits epsilon toxin and protects host cell death.
• Mapping the cellular diversity supporting neuro- and gliogenesis in the fast aging killifish brain
• Spatial mapping of cell diversity of the short lived African turquoise killifish telencephalon
• Retroviral vectors as a tool to study newborn neuron maturation and integration in the adult killifish telencephalon following injury
• Functional regeneration following injury in the telencephalon of the young killifish: a retroviral vector based approach
• Unlocking the gateway to successful neurorepair in the aged brain
• Mapping the progenitor diversity in the fast aging killifish brain
• Taking a deep dive into the progenitor diversity of the killifish brain
• Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential (vol 18, 346, 2019)
• Viral vector labeling of newborn neurons to study neurorepair in the forebrain of the African turquoise killifish
• Quantum Correlations in Symmetric Multiqubit Systems Showing 27 of 29
• Mapping the aging phenotype of the fast-aging killifish retina on a single cell level
• Transgenics in the African Turquoise killifish: friends or foe?
• Deciphering the fast-aging killifish retinal landscape on a single cell level
• The role of astrocyte subtypes in adult brain plasticity
• Manipulating astrocytic activity as a gateway to modulate adult neuroplasticity
• Radial glia and progenitor diversity in the brain of the fast-aging African turquoise killifish
• Chemogenetic manipulation of astrocyte activity at the synapse- a gateway to manage brain disease
• Early life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon
• Supression of Perforin-like Protein pores inhibit Plasmodium multistage-growth, transmission and erythrocyte senescence
• Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the Killifish N. furzeri
• Cellular heterogeneity of adult neurogenesis in the revolutionary turquoise killifish model
• Single-cell sequencing unravels the cellular diversity that shapes neuro- and gliogenesis in the fast aging killifish (N. furzeri) brain
• Plasmodium Perforin-Like Protein Pores on the Host Cell Membrane Contribute in Its Multistage Growth and Erythrocyte Senescence
• Benzoxazine derivatives of phytophenols show anti-plasmodial activity via sodium homeostasis disruption
• Targeted repression of Plasmodium apicortin by host microRNA impairs malaria parasite growth and invasion
• Age‐related dysregulation of the retinal transcriptome in African turquoise killifish
• Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential.
• Structural insights into a key carotenogenesis related enzyme phytoene synthase of P. falciparum: a novel drug target for malaria.
• Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri.
• Single‐cell sequencing unveils the impact of aging on the progenitor cell diversity in the telencephalon of the female killifish N. furzeri