Paul McLoughlin

Publications

• Publishing replication studies to support excellence in physiological research
• Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways.
• Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis.
• Pulmonary endothelial permeability and tissue fluid balance depend on the viscosity of the perfusion solution
• The relevance of basic sciences in undergraduate medical education
• Hypoxic pulmonary hypertension: The paradigm is changing
• Hypoxic pulmonary hypertension; the load on the right ventricle
• Elevated plasma CXCL12α is associated with α poorer prognosis in pulmonary arterial hypertension
• Obesity and lung disease: A toxic mix
• Pulmonary vascular dysfunction in ARDS
• The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance
• Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis
• Hypoxia-induced inflammation in the lung: A potential therapeutic target in acute lung injury?
• The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: Vasoconstrictor and structural mechanisms contribute equally
• Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO 2 sensing and signaling
• Physiological and pathological angiogenesis in the adult pulmonary circulation
• A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease
• Gremlin plays a key role in the pathogenesis of pulmonary hypertension
• Point:Counterpoint: Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature
• Last Word on Point:Counterpoint "Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature" [2]
• Statistics: All together now, one step at a time
• Statistics: All Together Now, One Step at a Time
• Statistics: All together now, one step at a time
• Statistics: All together now, one step at a time
• Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung
• Statistics: All together now, one step at a time
• NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells
• Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury
• Role of gremlin in the lung: Development and disease
• Permissive hypercapnia-role in protective lung ventilatory strategies
• Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis
• L-Arginine promotes angiogenesis in the chronically hypoxic lung: A novel mechanism ameliorating pulmonary hypertension
• Hypoxia selectively activates the CREB family of transcription factors in the In vivo lung
• Lung-selective gene responses to alveolar hypoxia: Potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension
• Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury
• Counterpoint: Chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature.
• Atelectasis causes alveolar injury in nonatelectatic lung regions
• Airway nitric oxide output is reduced in bronchiectasis
• Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection
• Hypoxic pulmonary vasoconstriction: Building a solid base
• High-Soluble-Fiber Diet Attenuates Hypoxia-Induced Vascular Remodeling and the Development of Hypoxic Pulmonary Hypertension
• Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells
• Gremlin 1 is required for macrophage M2 polarization
• Sex Dimorphism in Pulmonary Hypertension: The Role of the Sex Chromosomes
• Transcriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cells
• CAPILLARY LEAK AND EDEMA AFTER RESUSCITATION: THE POTENTIAL CONTRIBUTION OF REDUCED ENDOTHELIAL SHEAR STRESS CAUSED BY HEMODILUTION
• Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways
• Gremlin 1 blocks vascular endothelial growth factor signaling in the pulmonary microvascular endothelium
• Gremlin 1 depletion in vivo causes severe enteropathy and bone marrow failure
• The effects of genetic deletion of Macrophage migration inhibitory factor on the chronically hypoxic pulmonary circulation
• Permissive hypercapnia - Role in protective lung ventilatory strategies
• Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
• Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury
• Repeated measurement of the gas exchange threshold: Relative size of measurement and biological variabilities
• Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: Implications for vascular function in the eye
• Pulmonary hypertension [5] (multiple letters)
• Effect of changes in pH on wall tension in isolated rat pulmonary artery: Role of the RhoA/Rho-kinase pathway
• Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation.
• Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosis
• Chronic systemic hypoxia causes intra-retinal angiogenesis
• Permissive hypereapnia - Role in protective lung ventilatory strategies
• Interleukin-1β rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism
• Structural basis of hypoxic pulmonary hypertension: The modifying effect of chronic hypercapnia
• Hypercapnic Acidosis Attenuates Endotoxin-induced Acute Lung Injury
• Do gender differences exist in the ventilatory response to progressive exercise in males and females of average fitness?
• Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery
• Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation
• Type 2 nitric oxide synthase and protein nitration in chronic lung infection
• Erratum: Estimation of the gas exchange threshold in humans: A time series approach (European Journal of Applied Physiology (2001) vol. 85 (586-592))
• Combined confocal microscopy and stereology: A highly efficient and unbiased approach to quantitative structural measurement in tissues
• The structural basis of pulmonary hypertension in chronic lung disease: Remodelling, rarefaction or angiogenesis?
• Fetal heart rate response to strenuous maternal exercise: Not a predictor of fetal distress
• Exercise-related changes in umbilical and uterine artery waveforms as assessed by Doppler ultrasound scans
• Glucocorticoid treatment reduces exhaled nitric oxide in cystic fibrosis patients
• Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis
• Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis
• Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling
• Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs
• Lactate determination in exercise testing using an electrochemical analyser: With or without blood lysis?
• Chronic airway infection leads to angiogenesis in the pulmonary circulation
• Hypercapnia-induced contraction in isolated pulmonary arteries is endothelium-dependent
• Effects of changes in pH and P(co2) on wall tension in isolated rat intrapulmonary arteries
• Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis (multiple letters)
• Ventilatory response to incremental and constant-workload exercise in the presence of a thoracic restriction
• Irish thoracic society - Proceeds of annual scientific meeting held Friday & Saturday 8th & 9th November, 1996
• Exhaled nitric oxide and bronchoalveolar lavage nitrite/nitrate in active pulmonary sarcoidosis
• Potassium and ventilation during exercise above and below the ventilatory threshold
• Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent
• Effects of potassium and lactic acid on chemoreceptor discharge in anaesthetized cats
• Exercise-induced changes in plasma potassium and the ventilatory threshold in man
• Assessment of fitness in patients with cystic fibrosis and mild lung disease
• Effects of early plasmin digests of fibrinogen on isometric tension development in isolated rings of rat pulmonary artery
• Adaptation of carotid chemoreceptors to step increases in PaCO2 in anesthetized cats
• Effects of hypercapnia on steady state, phenylephrine-induced tension in isolated rings of rat pulmonary artery
• Exhaled nitric oxide is normal in sarcoidosis patients with active alveolitis
• Effects of intravenous infusions of KCl and lactic acid on chemoreceptor discharge in anaesthetized cats
• Effects of potassium and lactic acid on ventilation in anaesthetized cats
• The effect of intravenous infusion of lactic acid on carotid chemoreceptor discharge in anaesthetized cats ventilated with room air or 100% O2
• The effect of inspiration of 100% O2 on the ventilatory response to incremental exercise testing in man
• Afferent carotid chemoreceptor response to step increases in arterial P(CO2) in anaesthetized cats
• Use of arterialized venous blood sampling during incremental exercise tests
• Response of carotid chemoreceptors to elevated arterial potassium in anaesthetized cats ventilated with air or 100% oxygen
• Gentle exercise with a previously inactive muscle group hastens the decline of blood lactate concentration after strenuous exercise
• Shear stress-induced restoration of pulmonary microvascular endothelial barrier function following ischemia reperfusion injury requires VEGFR2 signaling