Marjan Slak Rupnik

Publications

• Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells.
• Acute respiratory acidosis and alkalosis - A modern quantitative interpretation,Akutna respiracijska acidoza in alkaloza - Sodobna kvantitativna interpretacija
• Network science of biological systems at different scales: A review.
• SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in β cell networks.
• Increased augmentation index and central systolic arterial pressure are associated with lower school and motor performance in young adolescents.
• Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH
• Measuring exocytosis in endocrine tissue slices
• Visualising the attributes of biological cells, based on human perception
• Collective sensing of β-cells generates the metabolic code
• Multilayer network representation of membrane potential and cytosolic calcium concentration dynamics in beta cells
• β Cells Operate Collectively to Help Maintain Glucose Homeostasis
• Autopoietic Influence Hierarchies in Pancreatic β Cells
• Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro.
• Loosening the shackles of scientific disciplines with network science: Reply to comments on “Network science of biological systems at different scales: A review”
• HUIEC, Human intestinal epithelial cell line with differentiated properties: process of isolation and characterisation.
• Platelet-rich plasma, especially when combined with a TGF-β inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro.
• Progressive glucose stimulation of islet beta cells reveals a transition from segregated to integrated modular functional connectivity patterns.
• Structural Similarities and Differences between the Human and the Mouse Pancreas.
• Collective Behavior of Social Bots Is Encoded in Their Temporal Twitter Activity.
• Heterogeneity and Delayed Activation as Hallmarks of Self-Organization and Criticality in Excitable Tissue
• Random matrix analysis of Ca$^{2+}$ signals in $β$-cell collectives
• The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance
• Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices
• Dual Mode of Action of Acetylcholine on Cytosolic Calcium Oscillations in Pancreatic Beta and Acinar Cells In Situ
• Dual Mode of Action of Acetylcholine on Cytosolic Calcium Oscillations in Pancreatic Beta and Acinar Cells in Situ
• Initiative on #4openScienceStandsForUkraine scientists and students
• Size-dependent effects of gold nanoparticles uptake on maturation and antitumor functions of human dendritic cells in vitro.
• Is tissue augmentation a reality in biosurgery? An experimental study of endothelial cell invasion into tissue filler.
• Rab3a ablation related changes in morphology of secretory vesicles in major endocrine pancreatic cells, pituitary melanotroph cells and adrenal gland chromaffin cells in mice.
• The relationship between membrane potential and calcium dynamics in glucose-stimulated beta cell syncytium in acute mouse pancreas tissue slices.
• A co-culture model of the developing small intestine offers new insight in the early immunomodulation of enterocytes and macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 translocation.
• Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.
• cAMP increases the sensitivity of exocytosis to Ca²+ primarily through protein kinase A in mouse pancreatic beta cells.
• ATP regulates sodium channel kinetics in pancreatic islet beta cells.
• In situ electrophysiological examination of pancreatic α cells in the streptozotocin-induced diabetes model, revealing the cellular basis of glucagon hypersecretion.
• Glucose-stimulated calcium dynamics in islets of Langerhans in acute mouse pancreas tissue slices.
• Functional connectivity in islets of Langerhans from mouse pancreas tissue slices.
• Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.
• AMPA receptors regulate exocytosis and insulin release in pancreatic β cells.
• Donor islet endothelial cells in pancreatic islet revascularization.
• Munc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently.
• Unperturbed islet α-cell function examined in mouse pancreas tissue slices.
• Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
• Myogenic progenitors and imaging single-cell flow analysis: a model to study commitment of adult muscle stem cells.
• Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology
• Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration.
• Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis.
• The relationship between node degree and dissipation rate in networks of diffusively coupled oscillators and its significance for pancreatic beta cells.
• Intracellular Ca2+ channels initiate physiological glucose signaling in beta cells examined in situ
• NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis
• Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells
• Calcium dependencies of regulated exocytosis in different endocrine cells
• Pancreatic beta cell lines and their applications in diabetes mellitus research.
• Enlargeosome, an exocytic vesicle resistant to nonionic detergents, undergoes endocytosis via a nonacidic route.
• All together now: exocytose or fail.
• Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.
• Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.
• Negative impact of endocrine-disrupting compounds on human reproductive health.
• Calcium dependencies of regulated exocytosis in different endocrine cells.
• Intracellular Cl- modulates Ca2+-induced exocytosis from rat melanotrophs through GTP-binding proteins.
• Pancreatic beta cell lines and their applications in diabetes mellitus research.
• Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation.
• The physiology of rodent beta-cells in pancreas slices.
• Phosphatidylinositol-4,5-bisphosphate-dependent facilitation of the ATP-dependent secretory activity in mouse pituitary cells.
• Exocytosis of insulin: in vivo maturation of mouse endocrine pancreas.
• The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4.
• Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics.
• Distinct role of Rab3A and Rab3B in secretory activity of rat melanotrophs.
• cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices.
• Embryonic stem cells differentiate into insulin-producing cells without selection of nestin-expressing cells.
• Glutamate stimulation increases hormone release in rat melanotrophs.
• Block of delayed-rectifier potassium channels by reduced haloperidol and related compounds in mouse cortical neurons.
• Cytosolic Cl- ions in the regulation of secretory and endocytotic activity in melanotrophs from mouse pituitary tissue slices.
• Endocytosis-dominated membrane area decrease requires Rab5 protein in rat melanotrophs.
• KATP-channels in beta-cells in tissue slices are directly modulated by millimolar ATP.
• Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells.
• Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells.
• Inhibition of ATP-sensitive potassium channels by haloperidol.
• Ammodytoxin, a neurotoxic secreted phospholipase A(2), can act in the cytosol of the nerve cell.
• In vivo and in vitro development of mouse pancreatic beta-cells in organotypic slices.
• Properties of Ca(2+)-dependent exocytosis in cultured astrocytes.
• Voltage-activated Ca(2+) channels and their role in the endocrine function of the pituitary gland in newborn and adult mice.
• A novel approach to in situ characterization of pancreatic beta-cells.
• Cardiovascular physiology: simulation of steady state and transient phenomena by using the equivalent electronic circuit.
• Modeling excess retrieval in rat melanotroph membrane capacitance records.
• Rapid regulated dense-core vesicle exocytosis requires the CAPS protein.
• The heterotrimeric Gi(3) protein acts in slow but not in fast exocytosis of rat melanotrophs.
• Mastoparan and Rab3AL peptide potentiation of calcium-independent secretory activity in rat melanotrophs is inhibited by GDPbetaS.
• Brefeldin A and a synthetic peptide to ADP-ribosylation factor (ARF) inhibit regulated exocytosis in melanotrophs.
• Osmotic swelling of hepatocytes increases membrane conductance but not membrane capacitance.
• Increased cytosolic chloride affects depolarization-induced changes in membrane capacitance and cytosolic calcium activity in rat melanotrophs.
• Cytosolic chloride ions stimulate Ca(2+)-induced exocytosis in melanotrophs.
• Prevalence of stochasticity in experimentally observed responses of pancreatic acinar cells to acetylcholine.
• The use of equivalent electronic circuits in simulating physiological processes
• The heterotrimeric Gi3 protein acts in slow but not in fast exocytosis of rat melanotrophs
• Cathophoresis paint insulated carbon fibre ultramicro disc electrode and its application to in vivo amperometric monitoring of quantal secretion from single rat melanotrophs
• Brefeldin A and a synthetic peptide to ADP-ribosylation factor (ARF) inhibit regulated exocytosis in melanotrophs
• Raising the cytosolic Ca2+ concentration increases the membrane capacitance of maize coleoptile protoplasts: Evidence for Ca2+-stimulated exocytosis
• Pancreatic regional blood flow links the endocrine and exocrine diseases
• The Effect of cAMP and the Role of Epac2A During Activation, Activity, and Deactivation of Beta Cell Networks
• Local Dialogues Between the Endocrine and Exocrine Cells in the Pancreas
• Sodium butyrate prevents cytokine‐induced β‐cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store‐operated calcium entry
• Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
• Improved analysis of membrane potential oscillations in the network of cells from islet of Langerhans
• Collective behaviour of social bots is encoded in their temporal Twitter activity
• Stromal Interaction Molecule 1 Maintains b-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling
• Collective sensing of β-cells generates the metabolic code at optimal islet size
• Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
• Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
• Corrigendum: Random Matrix Analysis of Ca2+ Signals in β-Cell Collectives (Frontiers in Physiology, (2019), 10, 10.3389/fphys.2019.01194)
• Physiological levels of adrenaline fail to stop pancreatic beta cell activity at unphysiologically high glucose levels
• SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in β cell networks
• Membrane potential and calcium dynamics in beta cells from mouse pancreas tissue slices: Theory, experimentation, and analysis
• Exendin-4 affects calcium signalling predominantly during activation and activity of beta cell networks in acute mouse pancreas tissue slices
• Critical transitions in pancreatic islets
• Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
• Tracking Ca2+ Dynamics in NOD Mouse Islets During Spontaneous Diabetes Development
• Functional characteristics of hub and wave-initiator cells in β cell networks
• Autopoietic Influence Hierarchies in Pancreatic Cells
• Collective biological computation of metabolic economy
• Confocal laser scanning microscopy of calcium dynamics in acute mouse pancreatic tissue slices
• Structural similarities and differences between the human and the mouse pancreas
• β-cells operate collectively to help maintain glucose homeostasis
• Critical and supercritical spatiotemporal calcium dynamics in beta cells
• High-resolution analysis of the cytosolic Ca2+ events in β cell collectives in situ
• Random matrix analysis of Ca2+ signals in β-cell collectives
• Network science of biological systems at different scales: A review
• Collective Behavior of Social Bots Is Encoded in Their Temporal Twitter Activity
• High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ
• Autopoietic influence hierarchies in pancreatic β cells
• Increased augmentation index and central systolic arterial pressure are associated with lower school and motor performance in young adolescents
• Dual mode of action of acetylcholine on cytosolic calcium oscillations in pancreatic beta and acinar cells in situ
• Short-term cognitive learning outcomes in team-based learning: is the permanent team important?
• Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
• The effect of forskolin and the role of Epac2A during activation, activity, and deactivation of beta cell networks
• HUIEC, Human intestinal epithelial cell line with differentiated properties: process of isolation and characterisation
• The relationship between node degree and dissipation rate in networks of diffusively coupled oscillators and its significance for pancreatic beta cells
• Random Matrix Analysis of Ca2+ Signals in β-Cell Collectives
• Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration
• pH-Dependence of Glucose-Dependent Activity of Beta Cell Networks in Acute Mouse Pancreatic Tissue Slice
• Tracking the evolution of functional connectivity patterns between pancreatic beta cells with multilayer network formalism
• Prevalence of stochasticity in experimentally observed responses of pancreatic acinar cells to acetylcholine
• Is tissue augmentation a reality in biosurgery? An experimental study of endothelial cell invasion into tissue filler
• Intergranule fusion in rat pars intermedia cells
• Opportunity makes a hub or a leader
• Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3Receptor-Specific Responses
• Microvascular homeostasis is compromised in pancreatic islets in a mouse model of beta cell loss and low-grade inflammation