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Jeffrey Saucerman

Publications

  • Graphical approach to model reduction for nonlinear biochemical networks
  • Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty
  • Multi-scale model of phospholamban mutations in the mouse heart
  • Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP
  • PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling
  • Multiscale model of heart growth during pregnancy: integrating mechanical and hormonal signaling
  • Local plantar pressure relief in therapeutic footwear: Design guidelines from finite element models
  • Mechanistic systems models of cell signaling networks: A case study of myocyte adrenergic regulation
  • Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: Comparison with a biochemical model
  • Multiscale modeling in rodent ventricular myocytes
  • Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling
  • Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca2 handling
  • Whole-genome metabolic network reconstruction and constraint-based modeling
  • Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts
  • Network model integrated with multi-omic data predicts MBNL1 signals that drive myofibroblast activation
  • Bigger, better, faster: Principles and models of AKAP anchoring protein signaling
  • Cardiac β-adrenergic signaling: From subcellular microdomains to heart failure
  • Endotoxin depresses heart rate variability in mice: Cytokine and steroid effects
  • Calmodulin binding proteins provide domains of local Ca 2+ signaling in cardiac myocytes
  • Computational models reduce complexity and accelerate insight into cardiac signaling networks
  • Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets
  • Phospholemman is a negative feed-forward regulator of Ca 2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy
  • Systems analysis of small signaling modules relevant to eight human diseases
  • Development and assessment of a novel systems bioengineering course integrating modeling and experimentation
  • A kinetic model of beta-adrenergic control in cardiac myocytes
  • Network analysis reveals a distinct axis of macrophage activation in response to conflicting inflammatory cues
  • Benchmarking of protein interaction databases for integration with manually reconstructed signalling network models
  • Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy
  • Dynamic map illuminates Hippo to cMyc module crosstalk driving cardiomyocyte proliferation
  • Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy
  • Benchmarking of protein interaction databases for integration with manually reconstructed signaling network models
  • Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues
  • Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy
  • Cardiac biexcitability: Two ways to catch a wave
  • Identification and characterization of Poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages
  • Erratum: Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP (Nature Chemical Biology (2012) 8 (375-382))
  • Cytokine screening identifies NICU patients with Gram-negative bacteremia
  • Automated image analysis of cardiac myocyte Ca 2+ dynamics
  • Cardiac Models in Drug Discovery and Development: A Review
  • Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes
  • Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
  • Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+
  • A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation
  • Computational Model Predicts Paracrine and Intracellular Drivers of Fibroblast Phenotype After Myocardial Infarction
  • Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction
  • Quantification of model and data uncertainty in a network analysis of cardiac myocyte mechanosignalling
  • Multiscale model of heart growth during pregnancy: Integrating mechanical and hormonal signaling
  • Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy
  • High-content live-cell imaging reveals co-regulation of cardiomyocyte decisions of hypertrophy and apoptosis
  • A kinetic model of beta-adrenergic control in cardiac myocytes
  • Modeling biochemical networks and excitation-contraction coupling
  • Modeling β-Adrenergic Control of Cardiac Myocyte Contractility in Silico
  • Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: Computational models of whole cells and heterogeneous tissue

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